Search Tag: PCC

ICU Management

Coagulopathy During Cardiac Surgery: The Role of Factor Concentrates

2019 26 Sep

The EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery.   The EACTS/EACTA guidelines were published jointly by the Society of Cardiothoracic Anesthesia and Cardiac Surgery for patient blood management. In the bleeding patient with a low fibrinogen level (<1.5 g/L), fibrinogen substitution may be considered to reduce... Read more

ICU Management

Treatment Options for Factor-Xa Inhibitor-Related Bleeding

2019 26 Sep

Specific treatment options for factor Xa inhibitor-related bleeding, focusing on drugs like rivaroxaban, apixaban, and edoxaban.   Non-vitamin K oral anticoagulants (NOACs/DOACs) are direct reversible inhibitors of factor Xa. These drugs are also reversible inhibitors versus warfarin or other vitamin K antagonist that are used in Europe. Anticoagulants... Read more

ICU Management

Prothrombin complex concentrates for rapid anticoagulation reversal before surgery

2018 06 Sep

Current guidelines for rapid anticoagulation reversal for emergency surgery recommend four-factor prothrombin complex concentrate (PCC) and vitamin K co-administration. A team of experts from the U.S., Canada and Germany reviewed the current evidence on PPC treatment for vitamin K antagonist reversal in the perioperative setting. Overall, the studies... Read more