Search Tag: ARDS

ICU Management

Impact of Treatment Variability on ARDS Mortality

2021 02 Nov

Acute Respiratory Distress Syndrome (ARDS) is a potentially fatal condition characterised by acute hypoxaemia, and bilateral radiographic infiltrates and a mortality of 36 to 47%. Interventions like lung protective ventilation (LPV) and prone positioning have been shown to improve survival but remain underused. Other treatment methods such as neuromuscular... Read more

ICU Management

Respiratory Subphenotypes of COVID-19-Related ARDS

2021 19 Oct

Patients with COVID-19 related ARDS present with distinct respiratory subphenotypes. But most phenotyping schema is limited by sample size, disregard for temporal dynamics and insufficient validation.   In the PRoVENT-COVID study, researchers aimed to identify respiratory subphenotypes of COVID-19-related ARDS. This was an investigator-initiated... Read more

ICU Management

Simultaneous Management of ARDS and sABI

2021 14 Sep

Acute respiratory distress syndrome (ARDS) occurs in approximately 40% of patients with severe acute brain injury (sABI), including acute ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage and traumatic brain injury. It is also a major determinant of morbidity and mortality.   With the increase in ARDS cases and reports of neurological... Read more

ICU Management

#ISICEM21: Findings from the REST Trial

2021 01 Sep

Acute hypoxaemic respiratory failure is a leading cause of admission to ICUs and is associated with significant mortality and morbidity. Many patients affected by acute hypoxaemic respiratory failure meet the diagnostic criteria for acute respiratory distress syndrome. An important intervention that has been shown to reduce mortality in patients with... Read more

ICU Management

Insights from the PRoVENT-COVID Study

2021 23 Aug

Mortality in patients with COVID-19 is much higher in patients who need invasive ventilation for acute respiratory distress syndrome (ARDS). COVID-19 patients with ARDS are a heterogeneous group with diverse evolutions that could be due to different phenotypes and response to care, including invasive ventilation strategies.   The Practice of VENTilation... Read more

ICU Management

Prone Positioning During ECMO for ARDS

2021 17 Aug

There is sufficient evidence to show that prone positioning improves oxygenation and respiratory mechanics and is also associated with lower mortality in patients with moderate to severe ARDS. However, some patients can develop refractory hypoxaemia and hypercapnia that could require the use of venovenous extracorporeal membrane oxygenation (VV-ECMO)... Read more

ICU Management

Precision Therapies for Heterogeneous ARDS Patients

2021 20 Jul

ARDS is a heterogeneous syndrome rather than a distinct disease. It is this heterogeneity that often makes it difficult to study treatments for patients with ARDS. Literature on ARDS is rife with clinical trials that do not show any mortality benefit.   Recent evidence suggests different sub-phenotypes within the heterogeneous patient population.... Read more

ICU Management

Association of Higher vs Lower PEEP on Mortality

2021 19 Jul

Mechanical ventilation is a life-saving strategy for critically ill patients. However, it can promote and/or exacerbate lung injury through several mechanisms, including alveolar overdistension and repetitive opening and closing of the alveoli and small airways. Positive end-expiratory pressure (PEEP) has been employed to prevent end-expiratory alveolar... Read more

ICU Management

Selection Criteria for Lung Transplantation in COVID-19 Patients

2021 06 Apr

In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with COVID-19. She thus became the first patient in Europe to receive a lung transplant for this indication. The Vienna lung transplantation... Read more

ICU Management

Corticosteroid Treatment in ARDS

2021 30 Mar

Acute respiratory distress syndrome (ARDS) is a life-threatening condition that is characterised by bilateral pulmonary infiltrates on chest imaging and refractory hypoxaemia. ARDS is common in critically ill patients in ICUs and is associated with significant mortality. Findings from a recent study show that approximately 10% of ICU patients suffered... Read more