Search Tag: imaging biomarkers
2025 09 Nov
Hepatocellular carcinoma (HCC) continues to drive significant morbidity and mortality. Microvascular invasion (MVI) is a key marker of aggressive biology, yet confirmation usually arrives only after surgery. An MRI-based approach now captures how uneven the tumour and its immediate surroundings appear on routine sequences, turning those patterns...Read more
2025 02 Sep
Microvascular invasion is a key histopathological feature linked to recurrence and poor survival in hepatocellular carcinoma, yet it is confirmed only after surgery, limiting its value for preoperative decision-making. A retrospective multicentre analysis of 655 surgically confirmed cases explored whether three-dimensional fractal dimension derived...Read more
2025 02 Sep
Microvascular invasion is a key histopathological feature linked to recurrence and poor survival in hepatocellular carcinoma, yet it is confirmed only after surgery, limiting its value for preoperative decision-making. A retrospective multicentre analysis of 655 surgically confirmed cases explored whether three-dimensional fractal dimension derived...Read more
2025 25 Aug
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with significant challenges in diagnosis, risk stratification and treatment selection. While imaging has long been a cornerstone of HCC diagnosis, emerging evidence supports its role in identifying prognostic and predictive markers. These markers offer...Read more
2025 25 Aug
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with significant challenges in diagnosis, risk stratification and treatment selection. While imaging has long been a cornerstone of HCC diagnosis, emerging evidence supports its role in identifying prognostic and predictive markers. These markers offer...Read more
2025 13 Aug
Radiomics enables the extraction of quantitative features from medical images, offering detailed descriptors of tumour physiology that surpass visual interpretation. These radiomic features can be used to predict tumour heterogeneity, aggressiveness, treatment response and survival outcomes, thereby advancing precision medicine. For these predictions...Read more
2025 06 Jul
Chronic back pain (CBP) remains a leading cause of disability across Europe, impacting over 80 million people and incurring high healthcare costs. Although CBP lacks a specific pathoanatomical origin in most cases, research increasingly points to the role of muscle composition—specifically lean muscle mass (LMM) and intermuscular adipose tissue...Read more
2025 12 May
Accurately identifying high tau burden in patients with Alzheimer disease (AD) is essential for diagnosis, prognosis and therapeutic decisions. While positron emission tomography (PET) quantitation techniques offer detailed insight, they rely on complex processing and specialised software. To streamline this process, researchers developed and...Read more
2025 25 Mar
The classification of human epidermal growth factor receptor 2 (HER2) expression in breast cancer has undergone significant transformation with the identification of HER2-low as a distinct category. Traditional assessment methods using immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) are invasive, costly and time-consuming,...Read more
2025 25 Mar
The classification of human epidermal growth factor receptor 2 (HER2) expression in breast cancer has undergone significant transformation with the identification of HER2-low as a distinct category. Traditional assessment methods using immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) are invasive, costly and time-consuming,...Read more
2024 16 Dec
Liver metastases (LM) account for a significant proportion of secondary tumours in solid organs, with colorectal cancer (CRC), breast cancer (BC) and pancreatic cancer (PC) being among the primary sources. Early detection and detailed characterisation of LM are critical for determining prognosis and guiding effective treatment strategies. While...Read more
2024 30 Nov
Intratumoural heterogeneity is a significant challenge in modern oncology, complicating accurate diagnosis and effective treatment planning. While widely employed, single-site biopsies often fail to capture the full range of genomic, molecular and histological variations within a tumour. As a result, diagnostic accuracy is compromised, and treatment...Read more