UltraPerformance Convergence Chromatography™ (UPC2®) is a broad-based, complementary analytical platform that is taking its place alongside of LC and GC as one of the three essential separation technologies for modern laboratory analysis. There are three main forms of chromatography: GC, LC, and now convergence chromatography (CC). While all three use a stationary phase to interact with compounds of interest and a mobile phase to move compounds through the stationary phase and achieve separation, the techniques differ mainly by the mobile phases used. GC is defined by using a gas as its mobile phase, LC is defined by using liquids as its mobile phase, and CC is defined by using both gas and liquids. It is this convergence of mobile phases in combination with a far greater choice of stationary phases that makes CC a powerful additional choice for laboratory scientists. Orthogonality you can rely on A major concern of scientists in regulated industries is that impurity, degradation peaks, or structurally similar compounds may be overlooked. Orthogonal methods that provide different elution orders of peaks are needed to ensure full characterization and that nothing is overlooked. Having a second technology platform that can routinely provide reliable orthogonal data is proving to be a strong driver for UPC2 adoption.