The 3D-Bioplotter® System is a suitable Rapid Prototyping tool for processing a great variety of biomaterials within the process of Computer Aided Tissue Engineering from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® System comes in two version to match the needs of varying users and budgets. The 3D-Bioplotter® Manufacturer Series offers all options needed by the advanced operator. Features: manufacturer5 different cartridges can be used during the same build job 1x Low and 1x High Temperature Head Particle and sterile filters Needle position control via high resolution camera Heating and cooling capabilities on building platform 4 external temperature sensor ports Semi automatic material calibration Automatic z-height controlling system for changeable platform add-ons, e.g. petri dishes PC with machine control software Automated nozzle cleaning process