The 3D-Bioplotter® System is a suitable Rapid Prototyping tool for processing a great variety of biomaterials within the process of Computer Aided Tissue Engineering from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. Tissue Engineering and Controlled Drug Release require 3D scaffolds with well defined external and internal structures. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular Rapid Prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. The 3D-Bioplotter® is specially designed for work in sterile environments in a laminar flowbox, a requirement of Biofabrication, for example when using alginate cell suspensions for scaffold construction. In contrast to other Rapid Prototyping techniques, the 3D-Bioplotter® uses a very simple and straightforward technology, invented and developed at the Freiburg Materials Research Centre in Germany.