The DrySyn Snowstorm offers an attractive solution to low temperature reaction chemistry. Purging the dome with nitrogen / argon prevents the formation of ice, around the reactors, at sub-ambient temperatures. Active temperature control from +150oC to -60oC permits unattended operation of up to 12 vials at any one time. With a small bench top footprint, the DrySyn Snowstorm allows increased throughput and screening without taking up valuable fume hood space.