High durability and pressure resistance enable high resolution performance. The application range of UHPLC can be extended from ultra high speed analysis to ultra high resolution analysis. The LaChromUltra II column is packed with grafted material comprised of organic-inorganic silica, providing improved physical and chemical durability over conventional silica gel particles. To maximize the high pressure performance inherent to UHPLC, a 250 mm long column with 1.9 µm particles is added to the product lineup. The applicability of UHPLC is extended from ultra high speed analysis to high resolution analysis.