Mapping the Fetal Brain: New Technique
The research, published online in Human Brain Mapping, examines the naturally developing default mode network in the human fetal brain. Fetal brains are in default mode much of the time, but it is not very well known how this network develops.
The researchers created a four-dimensional movie of fetal default mode network activity using functional MRI. While typically just one measurement is collected for each position at each time point, the team collected multiple measurements, each providing slightly different perspectives. Using the multiple measurements, they were able to reposition the images to create an estimate of what the activation over a period of a few minutes would look like.
After showing they could successfully quantify brain activity in moving subjects by testing the method on adults, the researchers scanned eight fetuses between 32 and 37 weeks of pregnancy, as infants born prematurely at that age have been shown to have active default mode networks. The resulting images were compiled to create a four-dimensional view of each of the brains over a five-minute time window.
“It really hasn’t been explored when these activity networks—these collections of brain areas that start to work together in the brain—emerge and what types of cells and tissues they emerge in,” says Colin Studholme, PhD, a professor with joint appointments in pediatrics and bioengineering at the University of Washington and senior author of the paper. “What this is leading to is not just collecting data from individual babies but also understanding and building a four-dimensional map of brain activity and how it should emerge in a normal baby.”
The technique has potential use in comparing brain development in premature and full-term babies; the effects of alcohol, drug use, or stress during pregnancy; or if there are any prenatal differences in babies that go on to develop neurodevelopmental disorders like autism. Studholme also plans to study the placenta and how its development influences the brain.
The team received support for this study from NIBIB the National Institue of Neurological Disorders and Stroke and the National Center for Advancing Translational Sciences.
Image caption: Functional MRI of a fetal brain, showing activated regions (red) of the default mode network—a collection of areas that are active when the brain is at rest. Image credit: S. Seshamani et al.
Video credit: Colin Studholme, Biomedical Image Computing Group, University of Washington.
Source: National Institute of Biomedical Imaging and Bioengineering
Published on : Mon, 17 Oct 2016
Explore the new dimension that you have never seen before WS80A with Elite is designed to create a new possibility for ultrasound diagnosis adopting new dimension that you have never seen before. The finest image quality, advanced 5D diagnostic solution...
Introducing a new chapter in ultrasound visualization technology. X-Porte was developed from the ground up to incorporate a breakthrough, proprietary beam-forming technology: XDI (Extreme Definition Imaging). This signal analysis algorithm shapes...
Based on Mindray's new generation ultrasound platform, mQuadro, M9 has raised the industry standards to an all new level. Advanced signal transmission and reception processors provide highly sensitive and accurate echo detection. Innovative transducer...
GM85 from Samsung is a mobile digital radiography system which allows easy navigation through anywhere with its compact design. Long lasting battery and superior user experience with SID Guide and S-Align deliver optimized workflow with enhanced usability....
UltraDrape is an innovative dressing designed for use during Ultrasound-Guided Peripheral Intravenous (UGPIV) that provides dual-action barrier and securement in one.