The CARS congress with its associated journal has issued an open invitation to potential attendees of the annual congress to take place in Berlin from June 22 – 25. With a focus on research and development for computer-assisted systems and their applications in radiology and surgery, CARS has played a leading role in medical informatics for more than 25 years. It has a close collaboration with the ISCAS, EuroPACS, CAR, CAD and CMI societies. Following the long-term successful cooperation, they will jointly hold their annual meetings with the 25th CARS Congress in Berlin in 2011. New PACS applications, including IT infrastructures adapted for the operating room as well as related results from the DICoM and IHE working groups are also within the scope of CARS.