Search Tag: vasopressors
2025 04 Sep
Sepsis is a life-threatening, dysregulated immune response often leading to hypotension and multisystem organ dysfunction, with acute kidney injury (AKI) being the most common organ failure in critically ill patients. Traditional broad therapies for sepsis have largely failed due to the heterogeneity of the syndrome. Recent approaches focus on ide1Read more
2025 27 Mar
The basics of vasopressor support and advanced considerations regarding its early use in intensive care settings. Introduction The use of vasopressors in critical care is a crucial aspect of haemodynamic management. While norepinephrine remains the primary agent of choice, the role of other vasopressors such as vasopressin has ga1Read more
2025 20 Mar
The MINUTES bundle was discussed in one of the sessions @ISICEM in Brussels. The MINUTES bundle is a structured approach designed to guide healthcare professionals in the initial 30-minute management of patients presenting with undifferentiated circulatory shock. The acronym stands for M aintain ABCs, IN fuse vasopressors and/or fluids, IN vest1Read more
2025 17 Feb
Vasopressors are commonly used in critically ill patients to increase vascular tone in cases of severe hypotension with signs of altered tissue perfusion, such as poor skin perfusion, altered mental status, or decreased urine output—indicative of shock. Shock is associated with elevated lactate levels (>2 mmol/L) and can be classified into four ty1Read more
2024 30 Apr
A recent study investigates the clinical factors influencing clinician decisions regarding fluid administration, vasopressor initiation, and vasopressor route in early sepsis. Previous concerns about fluid overload in sepsis have prompted interest in early vasopressor initiation, especially through peripheral IVs, as an alternative to central 1Read more
2023 22 Aug
In December 2017, angiotensin II (ATII) intravenous infusion gained approval in the U.S. for treating septic or other distributive shock in adults. This approval was based on results from a phase II clinical trial which showed higher mean arterial pressure in septic shock patients on norepinephrine, who were randomly assigned to titrated ATII comp1Read more
2023 20 Apr
When patients are critically ill, one or more organs may not function optimally or even fail, so organ support is an important component of ICU management. However, organ support can be associated with complications such as infections, bleeding, and damage to surrounding tissue or organs. These complications can alter the patient's conditi1Read more
2023 20 Apr
Vasopressors and inotropes are frequently used in intensive care units. With a special focus on recent studies, this article summarises the key messages in the management of patients requiring inotropes and vasopressors. Introduction Cardiac output (CO) is a key determinant of oxygen delivery. Low cardiac output syndrome (LCOS) caus1Read more
2022 16 Mar
An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis 1Read more
2022 16 Mar
In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 20211Read more
2019 03 Jun
On Day 2 of the Euroanaesthesia Congress 2019 (#EA19), there was a session on Resuscitation in septic shock: is less better? Three key speakers Gernot Marx (Aachen, Germany), Claude Martin (Marseille, France) and Jean-Louis Vincent (Brussels, Belgium), spoke about less fluid, less vasopressors and less inotropes in septic shock. The central me1Read more
2019 23 Apr
Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure. This article, published in the journal Critical Care, proposes the concept of “broad spectrum vas1Read more
2018 31 Oct
Researchers from Imperial College London have created an artificial intelligence system that could help treat patients with sepsis. Aptly named AI Clinician, the system could predict the best treatment strategy for patients. Tests conducted by the researchers showed that 98 percent of the time, the AI system matched or was better than the huma1Read more
2018 13 Sep
In the ICU setting, nearly 25 percent of patients who receive mechanical ventilation develop muscular weakness severe enough to impair their quality of life. New research shows that mechanically ventilated patients treated with vasopressor medications had a more than three-fold increase in the odds of developing ICU-associated weakness. N1Read more
2016 27 Sep
In this update review on vasoactive drugs in sepsis, we focus on the most recent data regarding the type of vasopressors that should be used, the timing of infusion, the mean arterial pressure target and the alternative approaches. Sepsis and especially septic shock is associated with arterial vasodilation refractory to fluid challe1Read more