Search Tag: septic shock
2025 07 Jan
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Sepsis involves both pro-inflammatory and anti-inflammatory processes, which can occur early in the disease and explain the severe clinical outcomes such as septic shock and premature death. However, each patient follows a unique...Read more
2024 28 Nov
Vasopressin timing, patient selection, optimal vasopressin use in septic shock, and potential mortality benefits in selected patient populations. Septic Shock Overview and Current Treatments Septic shock is a severe, life-threatening response to infection, characterised by systemic inflammation, tissue hypoperfusion, and persistent,...Read more
2024 26 Nov
Vasoactive drugs are commonly prescribed to critically ill adult patients in ICUs, with noradrenaline being the first-line treatment for septic shock. Vasopressin, a second-line vasopressor, is also widely used. However, there is uncertainty regarding the timing of vasopressin initiation. The VASST and VANISH trials, which investigated vasopressin...Read more
2024 02 Jul
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. The Sepsis-related Organ Failure Assessment (SOFA) score, developed in 1996, quantifies organ dysfunction across six systems: neurological, cardiovascular, respiratory, renal, liver, and coagulation. Initially specific to sepsis, the SOFA score is widely...Read more
2024 16 May
Sepsis affects approximately 49 million people worldwide each year. To reduce the mortality rate and the global burden of sepsis, the World Health Organization has classified it as a priority research area. When combined with surgical trauma, anaesthetic drugs, and various invasive procedures, the impact intensifies, leading to further impairment...Read more
2024 28 Feb
International guidelines recommend using corticosteroids for adults with septic shock who require vasopressor therapy, supported by moderate-quality evidence. While corticosteroids may shorten the duration of shock, their impact on mortality remains uncertain. A recent meta-analysis found no significant reduction in mortality among septic shock...Read more
2024 13 Feb
In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortisone on patients with community-acquired pneumonia (CAP) compared to those with non-CAP-related septic shock. The goal was to determine whether glucocorticoids...Read more
2024 23 Jan
In 2017, an estimated 25 million children worldwide experienced sepsis, resulting in over 3 million deaths. Paediatric sepsis survivors often face ongoing physical, cognitive, emotional, and psychological challenges. Children, particularly in lower-resource settings, face a higher risk of developing sepsis during their early years. The World Health...Read more
2024 12 Jan
Sepsis is a prominent cause of mortality in ICUs. Despite extensive research on the dynamics leading to sepsis, the role of cytokines—immune system molecules that can cause substantial harm to the body—has remained inadequately understood. While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine...Read more
2023 13 Oct
Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...Read more
2023 12 Sep
A woman came to see me a few days ago: her 44-year-old husband recently died from sepsis in another hospital, and she wanted to have a discussion about this tragic story. Her husband had had just some kind of blister on his foot. He didn’t seem very ill when he arrived at the hospital, but he quickly developed an extended area of fasciitis on his left...Read more
2023 06 Sep
Kidney injury frequently occurs in patients with septic shock and is linked to worse clinical outcomes. Administering thiamine (vitamin B1) as part of a mitochondrial resuscitation strategy might help mitigate septic kidney injury. Thiamine is crucial for aerobic respiration, and thiamine can lead to organ dysfunction. Because the kidney contains...Read more
2023 01 Aug
Vasopressin is a potent vasopressor used to treat septic shock, acting via a different receptor than catecholamines. Previous randomised control trials have demonstrated its efficacy. However, its use can also lead to adverse effects such as ischaemia events. Therefore, it is recommended as a second-line agent after noradrenaline. Typically,...Read more
2023 13 Jun
Despite advancements in medical care, sepsis remains a significant global health issue and a leading cause of hospital mortality worldwide. Numerous epidemiological studies have been conducted on sepsis, but its epidemiology remains unclear due to its heterogeneous nature. Sepsis is characterised by an imbalanced immune response to infection....Read more
2023 09 May
A new study assessed the impact of high mean arterial pressure (MAP) on renal outcomes in critically ill cirrhosis patients with septic shock (CIC). The efficacy of a high MAP strategy (80-85 mm Hg; H-MAP) was compared to a low MAP strategy (60-65 mm Hg; L-MAP) in improving 28-day mortality in CIC. Additionally, the study examined the reversal of shock,...Read more
2023 05 Apr
Volume expansion, the initial therapeutic measure for septic shock, involves the intravenous injection of a few hundred millilitres of fluid over a few minutes. However, using fluids in septic patients is a complex strategy, with various types of fluids available. The effects of fluid boluses are inconsistent and transient, and fluids carry risks,...Read more
2023 15 Feb
Sepsis and septic shock are significant causes of morbidity and mortality in critical care, with a complex and rapidly evolving clinical presentation. This involves microbial invasion, infection focus, immune response, circulating pathogen and pathogen products, immunodysregulation, organ damage, and multiple organ dysfunction. Extracorporeal therapies...Read more
2022 25 Oct
Septic shock is one of the most severe complications of any infection. It affects millions of people each year. Studies show that in the U.S. and Europe, nearly 10% of patients admitted to the ICU have septic shock. Significant efforts have been made to recognise and treat septic shock early. Still, over 50% of patients die of septic shock within days...Read more
2022 11 Oct
Over 50 million people worldwide suffer from sepsis every year. Sepsis causes nearly 11 million deaths and is responsible for one-third to half of all in-hospital deaths. The mortality rate for sepsis ranges from 10 to 20%. For septic shock, the most serious form of sepsis, the mortality rate can range from 50 to 60%. Guidelines recommend early...Read more
2022 27 Sep
Source control is important in the treatment of sepsis and septic shock. Lack or delay of source control can result in worse outcomes for patients. The 2021 Surviving Sepsis Campaign guidelines recommend identifying the anatomical source of infection that requires source control and implementing it as soon as possible. However, adequate source...Read more
2022 26 Jul
Sepsis is a life-threatening disease with high mortality. More than 10,000 people die from sepsis every year in Japan. Septic shock is when sepsis is associated with circulatory and cellular metabolic abnormalities. International guidelines recommend the use of antimicrobial therapy and source control with drainage or surgery, intensive care with fluid...Read more
2022 16 Mar
Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly 14 million adults and 2.5 million children survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...Read more
2022 16 Mar
An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Campaign...Read more
2022 16 Mar
An overview of the haemodynamic management of patients in septic shock and strategies for detection of haemodynamic changes and appropriate therapeutic action to improve the prognosis of these patients. Introduction Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ...Read more
2022 15 Feb
Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid...Read more
2022 01 Feb
Sepsis is a life threatening condition with an estimated 49 million cases worldwide and 11 million deaths. It involves organ dysfunction due to a dysregulated host response to infection. Sepsis continues to be a global health issue and is is responsible for approximately 20% of annual global deaths. Sepsis is typically managed through intravenous...Read more