Search Tag: procalcitonin

Sepsis

Diagnostic Accuracy of Monocyte Distribution Width, Procalcitonin and C‐Reactive Protein

2023 09 May

Sepsis is characterised by a dysregulated host response to infection resulting in organ dysfunction. It poses a significant global health problem, with a high mortality risk and millions of patients affected annually. Epidemiological studies have shown that nearly 20% of septic patients require mechanical ventilation, leading to significant healthcare... Read more

ICU Management

Biomarkers as Prognostic Predictors and Guide in Critically Ill Patients

2023 20 Apr

An overview of promising biomarkers in critical care, characteristics a biomarker should have and how to ensure their usefulness in clinical practice.   Introduction   Precision medicine is a medical approach that tailors treatments based on individual patient characteristics and their unique response to therapies for a particular disease.... Read more

ICU Management

Volume 23 - Issue 1, 2023

2023 13 Mar

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ICU Management

Biomarkers in Sepsis

2023 13 Mar

This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for  Biomarkers  in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated... Read more

ICU Management

The PSP Biomarker Rises Earlier than CRP and PCT in Sepsis, a New Study Shows

2021 20 Apr

Sepsis is a global healthcare problem, with 50 million cases each year and 11 million related deaths  1 . It’s the life-threatening complication of an infection, in which the host’s immune response to a pathogen damages its own organs. The clinical diagnosis of sepsis relies mostly on signs and symptoms that are neither sensitive nor specific enough... Read more

Sepsis

The PSP Biomarker Rises Earlier than CRP and PCT in Sepsis, a New Study Shows

2021 20 Apr

Sepsis is a global healthcare problem, with 50 million cases each year and 11 million related deaths  1 . It’s the life-threatening complication of an infection, in which the host’s immune response to a pathogen damages its own organs. The clinical diagnosis of sepsis relies mostly on signs and symptoms that are neither sensitive nor specific enough... Read more

ICU Management

COVID-19 and Antimicrobial Stewardship

2020 19 Oct

COVID-19 is a new disease. On initial presentation, clinicians can find it difficult to differentiate between coronavirus disease and bacterial community-acquired pneumonia. COVID-19 patients often develop a hyperinflammatory phase during the disease process, which could again be difficult to distinguish from a secondary bacterial infection. That is... Read more

Health Management

The Role of Procalcitonin for Risk Assessment and Treatment of COVID-19 Patients

2020 03 Aug

Procalcitonin is widely used to assess the risk of bacterial infection and disease progression. Can it be an additional tool to identify COVID-19 patients at risk of severe disease? Key Points Procalcitonin (PCT) is a widely used biomarker to assess the risk of bacterial infection and disease progression. Early evidence... Read more

ICU Management

Procalcitonin-Guided Antibiotic Therapy in Severely Critically Ill Patients

2019 30 Aug

The controversy surrounding the efficacy of the blood infection biomarker, procalcitonin (PCT), for guidance in acute infections and sepsis treatment remains. PCT is a calcitonin precursor produced by epithelial cells when infected with bacteria and has been identified as a marker due to the protein levels’ variation upon infection initiation and cessation.... Read more

ICU Management

PCT-guided antibiotic treatment improves outcomes in sepsis patients

2018 22 Aug

Procalcitonin (PCT)-guided antibiotic treatment in ICU patients with infection and sepsis patients results in improved survival and reduced antibiotic treatment duration, according to results of a new meta-analysis published in the journal Critical Care. Early identification of sepsis and appropriate initial management including the start of... Read more