Search Tag: hydrocortisone

ICU Management

VITAMINS Trial: No Significant Benefit of Vitamin C Cocktail

2020 22 Jan

Sepsis is a life-threatening condition that causes nearly one-third to half of all hospital deaths. It is also responsible for more than 5 million deaths worldwide each year. Patients with septic shock are an important subgroup of sepsis. These patients have circulatory and metabolic abnormalities that further increase their mortality risk. New treatments... Read more

ICU Management

Top ICU Stories of 2019

2019 28 Dec

As we move into 2020, here's a quick recap of our most clicked stories in ICU in 2019:  Using Biomarkers for Mortality Prediction in Patients With Sepsis A new study evaluated the prognostic value of six biomarkers at onset of sepsis in adult patients with sepsis or septic shock. Risk Factors for Frailty and Death in the ICU... Read more

ICU Management

Hydrocortisone Versus Placebo in Patients with Septic Shock

2019 01 Dec

Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these... Read more

ICU Management

Vitamin C Drug Cocktail for Sepsis

2019 09 Jul

The combination of intravenous vitamin C, corticosteroids and thiamine has been made famous by Dr. Paul Marik, M.D. for the treatment of sepsis in critically ill patients. The ‘Marik protocol’, also termed HAT (Hydrocortisone, Ascorbic acid, Thiamine), has however come under criticism regarding the lack of evidence. Dr. Marik of Sentara Norfolk... Read more

ICU Management

Hydrocortisone in Severe Sepsis: HYPRESS Trial Results

2016 03 Oct

The results of the first randomised controlled trial investigating the effects of adjunctive early low-dose hydrocortisone to prevent progression to shock in patients with severe sepsis presenting without shock are published in JAMA today. There were no significant differences between treatment groups with regard to mortality or length of stay in... Read more