Search Tag: PEEP
2024 21 Oct
In mechanically ventilated patients with acute respiratory distress syndrome (ARDS), the use of positive end-expiratory pressure (PEEP) presents a therapeutic dilemma. PEEP can improve gas exchange and lung mechanics but may impair haemodynamics. Its effects primarily impact right ventricular (RV) preload and afterload, while left ventricular (LV)...Read more
2024 09 Oct
Approximately 20 million individuals globally undergo mechanical ventilation each year, and this number is expected to increase. While lifesaving, invasive ventilation can lead to complications, with 40% of ventilated time spent on liberating patients from the ventilator. Reducing the duration of mechanical ventilation is a key research priority...Read more
2023 06 Dec
ARDS is a life-threatening respiratory failure characterised by acute hypoxaemia and bilateral radiographic infiltrates. The definition of ARDS has evolved over 50 years, with recent suggestions to include intubated and non-intubated patients. Management remains largely supportive, focusing on strategies to limit lung injury, but high mortality rates...Read more
2023 13 Oct
In this article, we will examine clinical concepts that have persisted over time, despite advancements in our understanding of physiology and technological innovations that have demonstrated their inapplicability in the routine clinical care of paediatric patients requiring respiratory support. These enduring beliefs have effectively transformed...Read more
2022 02 Aug
Optimal positive end-expiratory pressure (PEEP) level during mechanical ventilation for COVID-19 pneumonia remains debated. A third of experts in a recent consensus statement supported a low-level PEEP for COVID-19-related acute respiratory failure (C-ARDS), with half of the panel remaining neutral without agreement on PEEP titration. However, the...Read more
2022 05 Jul
There have been conflicting results concerning lung recruitability of COVID-19 acute respiratory distress syndrome (ARDS) and the use of techniques derived from changes in respiratory mechanics and/or gas exchange in response to positive end-expiratory pressure (PEEP) increase. Various factors may explain the heterogeneity of reports regarding recruitability...Read more
2021 20 Jul
ARDS is a heterogeneous syndrome rather than a distinct disease. It is this heterogeneity that often makes it difficult to study treatments for patients with ARDS. Literature on ARDS is rife with clinical trials that do not show any mortality benefit. Recent evidence suggests different sub-phenotypes within the heterogeneous patient population....Read more
2021 19 Jul
Mechanical ventilation is a life-saving strategy for critically ill patients. However, it can promote and/or exacerbate lung injury through several mechanisms, including alveolar overdistension and repetitive opening and closing of the alveoli and small airways. Positive end-expiratory pressure (PEEP) has been employed to prevent end-expiratory alveolar...Read more
2019 30 Aug
Acute Respiratory Distress Syndrome (ARDS) affects up to 10% of patients in the ICU. Typical symptoms of ARDS include an increase in lung weight and a reduction of aerated lung tissue. For the treatment of ARDS alveolar recruitment is key, however, this has not yet been shown to benefit severe ARDS cases. It has been suggested that lung recruitment...Read more
2017 21 Mar
Among patients with hypoxaemia after cardiac surgery, the use of an intensive alveolar recruitment strategy compared with a moderate recruitment strategy resulted in less severe pulmonary complications during the hospital stay, according to a randomised clinical trial of postoperative ventilation published in JAMA. See Also : Towards Safer Ventilation...Read more
2015 29 Oct
Choose an optimal PEEP setting with the help of the transpulmonary pressure measurement on our high-end ventilators, HAMILTON-G5 and HAMILTON-S1 . Acute respiratory distress syndrome (ARDS) is characterized by a decrease in respiratory system compliance due to a collapsed lung and/or a decrease in chest wall compliance. When mechanical ventilation...Read more