Search Tag: Levosimendan
2019 26 Aug
Summary: Calcium activation and calcium sensitivity in the failing myocardium. Historically, treatment of heart failure with inotropic agents started with the employment of extracts of foxglove, which contained a mixture of cardiac glycosides. With their low therapeutic margin due to a resulting ionic dysbalance though, cardiac glycosides...Read more
2019 10 Jan
Levosimendan is an inodilator that promotes cardiac contractility primarily through calcium sensitisation of cardiac troponin C and vasodilatation via opening of adenosine triphosphate-sensitive potassium (KATP) channels in vascular smooth muscle cells. The drug also exerts organ-protective effects through a similar effect on mitochondrial KATP...Read more
2017 24 Oct
In patients undergoing cardiac surgery, the benefit of levosimendan in terms of survival was not shown in multicentre or in high-quality trials; however, levosimendan therapy was associated with reduced mortality in patients with preoperative ventricular systolic dysfunction, according to a new meta-analysis published in the journal Critical Care....Read more
2017 21 Mar
In patients who required perioperative hemodynamic support after cardiac surgery, low-dose levosimendan in addition to standard care did not result in lower 30-day mortality than placebo, according to a multicentre study published in The New England Journal of Medicine. See Also : Categorisation of Survival and Death after Cardiac Arrest Every...Read more