Search Tag: Angiotensin II
2025 17 Feb
Vasopressors are commonly used in critically ill patients to increase vascular tone in cases of severe hypotension with signs of altered tissue perfusion, such as poor skin perfusion, altered mental status, or decreased urine output—indicative of shock. Shock is associated with elevated lactate levels (>2 mmol/L) and can be classified into four types:...Read more
2023 22 Aug
In December 2017, angiotensin II (ATII) intravenous infusion gained approval in the U.S. for treating septic or other distributive shock in adults. This approval was based on results from a phase II clinical trial which showed higher mean arterial pressure in septic shock patients on norepinephrine, who were randomly assigned to titrated ATII compared...Read more
2020 14 Sep
Post cardiopulmonary bypass vasoplegia is common, and associated with poor outcomes. Traditional management strategies involving escalating doses of catecholamines, vasopressin and adjuncts such as methylene blue and hydroxycobalamin or ascorbic acid have not shown promising results. Since ACE enzyme dysfunction, high serum renin and low endogenous...Read more