Search Tag: ABI

2026 21 Apr

There is an under-recognised methodological challenge in randomised clinical trials (RCTs) involving patients with acute brain injury (ABI): the impact of withdrawal of life-sustaining treatment (WLST) on trial validity and interpretation. WLST represents a significant and often inadequately reported source of bias that can distort estimates of tr1Read more

2025 19 Nov

A recent study examined whether low-tidal-volume ventilation (LTVV) is associated with lower mortality in mechanically ventilated patients with acute brain injury (ABI).    LTVV has become standard care in patients with acute respiratory distress syndrome (ARDS) but its use in the ABI population remains controversial due to concerns about in1Read more

2025 12 May

Maintaining proper cerebral oxygen delivery is crucial for preventing secondary ischaemic injury in patients with acute brain injuries (ABI). Arterial carbon dioxide tension (PaCO₂) significantly influences cerebral blood flow (CBF). When intracranial pressure (ICP) is not elevated, adjusting PaCO₂ to an optimal level can support sufficient cerebr1Read more

2025 18 Mar

The decision to withdraw or withhold life-sustaining therapies (WLST) is a significant factor in many ICU deaths, influenced by patient factors such as age, comorbidities, illness severity, and patient or surrogate preferences. In patients with acute brain injuries (ABIs), WLST decisions may be particularly influenced by expectations of poor neuro1Read more

2023 13 Jun

Acute brain injury (BI) affects millions of patients each year, with high mortality rates and significant disability. Invasive mechanical ventilation is often required for the most severe cases of BI. These patients frequently experience respiratory complications, such as ventilator-associated pneumonia and acute respiratory distress syndrome, whi1Read more