Since its inception in 1993, ZyDoc's mission has been to increase the efficiency of physicians through the use of software technology and services to improve patient care and outcomes, lower malpractice risk, and maximize reimbursement.

In 1993, ZyDoc released one of the first multimedia electronic medical records (EMR) as envisioned by the Institute of Medicine. The prototype was purchased by the Department of Defense and helped serve as a paradigm for the industry. ZyDoc immediately recognized the problem of the data entry bottleneck inherent in the EMR and has been pursuing solutions since then.

The founder, James Maisel, M.D., a retina surgeon, became involved in medical informatics and served as the Chairman of Healthcare Open Systems and Trials (HOST) in 1998. ZyDoc left the EMR arena in 2000 to develop other solutions that would be more efficient for physicians.