Immunoluminometric Assay (ILMA) for the determination of bioactive Adrenomedullin (bio-ADM) in human EDTA plasma
Bioactive Adrenomedullin (bio-ADM)
bio-ADM is the bioactive form of Adrenomedullin, a soluble 52 amino acid peptide hormone that is mainly released by vascular smooth muscle and endothelial cells. bio-ADM is an important regulator of vasodilation, blood pressure and organ perfusion  .
Prediction and Early Diagnosis of Shock & Guidance of Vasopressor Therapy
Elevated bio-ADM plasma levels predict numerous adverse endpoints for patients in acute care settings such as sepsis , acute myocardial infarction , and acute heart failure , as well as vasopressor demand in patients with septic shock , independently of other risk factors.
sphingotest® bio-ADM is an immunoluminometric assay (ILMA) for the determination of bio-ADM in human EDTA plasma. It represents the only available in vitro diagnostic (IVD) assay for the measurement of bioactive Adrenomedullin. One of the two sandwich antibodies is luminescent-labelled (tracer antibody) and highly specific for the amidated C-terminus of bio-ADM. The other antibody is immobilized to the wells of the microtiter plate (capture antibody) and specific for an internal epitope that is distant to the degradation-prone N-terminus of bio-ADM, resulting in increased analyte stability.
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