The use of the BioStream™ PTCA catheter is indicated for patients with discrete lesions of the coronary arteries with a reference vessel diameter of 1.50 to 4.00 mm for the purpose of improving the coronary lumen diameter. The BioStream™ PTCA catheter is indicated for the dilatation of the affected segments of a coronary artery or a coronary bypass in order to enhance myocardial perfusion. The BioStream paclitaxel eluting coronary balloon catheter is especially indicated for the treatment of coronary in-stent restenosis.