The Down-Cross system was designed to enable the operator to handle and dispense non-sterile products with powders and/or volatile compounds so that pharmaceutical product batches can be weighed and prepared entirely under LAF (Laminar Air Flow). The features of the cabinet can guarantee protection of the operator, product and surrounding environment. The operator and the product are protected from cross-contamination by containing powder handling within the area, thanks to a slightly lower pressure inside the cabinet compared to the outside environment and to an airflow barrier installed at the front opening to allow work operations.