The HPLC systems are known to be widely used systems these days and are used in various fields. It is known to be highly reliable in analysing of data and greater efficiency can also be got in complete analysis workflow. This will ensure quick advancement in the field of manufacturing of new drugs, great food safety and also meets high standards in the environmental regulations. Numerous analysis techniques make use of LCMS that require front-end HPLC system for the sake of providing solvent delivery performance in micro to semi-micro range and injectors with low sample carryover. Prominence is also a network-ready HPLC system, which has been successful in meeting of needs of the advanced users these days. Prominence features the world's first Web control, highest detection sensitivity and fastest sample injection. Great productivity is ensured as it is fully automated and system is controlled with the help of a web browser.