The LCMS-8040 is an amazing device that is featured with the latest improved ion optics and collision cell technology. Due to this, it provides with greater multiple reaction monitoring sensitivity. The improvements with this device will ensure high sensitivity for the purpose of scan mode measurements and also helps by expanding potential range of LC/MS/MS applications. In this device, there has been a 5 fold development in the sensitivity. High speed is always maintained by this device. Ultrafast MRM transition increases up to 555 MRMs per second and this is successfully achieved by Shimadzus UFsweeper™ collision cell technology and the superior high-precision quadrupole machining capabilities. It is known to be backed by the high voltage power supply technology. The three main components of this device are that it is ultra-high speed, ultra-high reliable and ultra-high sensitive. It requires only a few minutes to perform and this is done in an effective manner.