The cHiPLC system from Eksigent is a chip-based unit that can operate with the ekspert nanoLC 400 system. It is a sensitive unit that can handle three microfluidic chips at a time. It is very flexible in its body and can handle a 10-port nano valve that is easy to switch around. This can handle many experiments and works with direct injection and trap-loading settings. The nanoLC chips or trap column chips on this unit can be exchanged in a very short period of time. The connection is used to align the setup right while microfabrication units are made to get this all ready to use. The techniques used here are made to find fluidic paths and to get a wear structure ready to make it easier for particles to be retained. The chips are also temperature controlled to ensure that the retention processes for the units are very easy to manage.