The Leica FL400* in combination with the active substance 5-ALA helps to see the tumor more clearly for a more complete resection of malignant glioma, while sparing healthy brain tissue. Before surgery, the patient drinks the 5-ALA solution. The aminolevulinic acid is absorbed by the cells in the body, whereas the glioma cells take up more and convert 5-ALA into the fluorescent PPIX. When illuminated under blue light the PPIX in the tumor glows an intense red, while the normal tissue appears blue. * The Leica FL400 is not approved for sale in the USA, Japan, and some other countries. Please contact your local Leica Microsystems sales representative for further information.