The CF100 performs cascade filtration on plasma received from any primary plasma separator (centrifugation or filtration devices) to which it is connected through only the plasma inlet and outlet tubes. The CF100 does the automatic priming of the disposable set before treatment, in order to make sure that all safety relevant criteria are met and then monitors the cascade filter to provide automatic rinsing by flush whenever necessary. This rinsing is mandatory to maintain the filter’s ability to remove specific substances within its optimal conditions.