• Introduction to Landiolol in Acute Cardiac Care

      An overview of landiolol, a potent and cardioselective beta-blocker offering a promising addition to the armamentarium for managing acute cardiac conditions for rapid and effective rate control with minimal adverse effects.   Cardiac emergencies present complex challenges in emergency medical settings, requiring prompt and effective management...

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  • Treating the Whole Human In Intensive Care – Patient-Centred Outcomes in Sepsis, Surgery and Trauma

    Intensive care impacts more than the patient, with ripple effects for families, employers and wider societies. Patient-centred outcomes reiterate the need for clinical therapies targeting the biological circuitry of the big-hitting syndromes like ARDS, sepsis, delirium, renal failure and recognising they persist beyond the veil of discharge....

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  • Cardiovascular Management in Septic Shock: Optimising Vascular and Cardiac Function

    An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia.    Optimising Vasopressin Initiation in Septic Shock   Patients with septic shock, and especially...

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  • Cardiovascular Management in Sepsis: Improving Cardiac and Vascular Functions

    Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management.     Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...

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  • Why Artificial Intelligence is Not Fixing the Problem of Sepsis in the Hospital

    The use of Artificial Intelligence in detecting sepsis, AI prediction/detection models and how these healthcare tools need to complement clinical expertise.     The potential of Artificial Intelligence (AI) in healthcare has generated significant excitement and discussion. However, it's important to distinguish between the theoretical...

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  • Applying International Sepsis Guidelines by Screening High-Risk Hospitalised Patients With PSP

    Hospital and ICU nosocomial sepsis screening for acutely ill and high-risk patients and daily measurement of PSP to diagnose nosocomial sepsis three to five days before the onset of symptoms.     Introduction Sepsis is a major public health threat and is responsible for 11 million deaths per year (Rudd et al. 2020) among 48.9 million cases....

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  • Biomarkers as Prognostic Predictors and Guide in Critically Ill Patients

    An overview of promising biomarkers in critical care, characteristics a biomarker should have and how to ensure their usefulness in clinical practice.   Introduction   Precision medicine is a medical approach that tailors treatments based on individual patient characteristics and their unique response to therapies for a particular disease....

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  • Biomarkers in Sepsis

    This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for  Biomarkers  in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated...

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  • Sepsis Diagnosis: Pancreatic Stone Protein in Adults, Children, and Neonates

    Based on the concepts and the checklist criteria for an ideal sepsis biomarker presented in the article Sepsis Diagnosis: Clinical signs, Scores, and Biomarkers in this issue of ICU Management & Practice , we update and review the potential use of Pancreatic Stone Protein (PSP) in adults, children, and neonates.     Pancreatic Stone...

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  • Tachycardia in Sepsis: Friend or Foe?

    An overview of tachycardia in sepsis, the importance of rate control and the beneficial effects of beta-blockers.         Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes...

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