Ivabradine Does Not Improve HFpEF Patient Outcomes
A randomised trial has just been completed in which patients with heart failure with preserved ejection fraction (HFpEF) were treated with Ivabradine. Currently, there is no known effective treatment for reducing morbidity and mortaility in patients suffering from HFpEF.
See Also: Azithromycin Not Linked to Increased Arrhythmia Risk
HFpEF patients tend to suffer from elevated heart rate which is a predictive factor of poor outcomes and increased mortality. Trial findings did not find any improvement in outcomes with ivabradine despite the fact that previous research had suggested that the drug could possibly benefit patients with heart failure with reduced ejection fraction.
"Potential explanations for failure are lack of sufficient power since recruitment was interrupted due to difficulties in finding patients, and the idea that heart rate lowering is beneficial in this condition could be wrong if patients have extensive fibrosis and thus no reserve in stroke volume. In that case, changes in cardiac output are totally dependent of heart rate, and reducing heart rate in this context could be detrimental," said Prof. Michel Komajda, lead author of the European Journal of Heart Failure study.
Image Credit: MarinaVladivostok
Published on : Mon, 8 May 2017
The CNAP® Monitor 500 HD standalone is designed for continuous noninvasive hemodynamic monitoring in a wide range of applications, i.e. electrophysiology, operating theatres, critical- and intermediate care, emergency room and transport.
Proven 6-channel ECG performance The most important cardiopulmonary function tests are combined in one single device: resting ECG and exercise ECG. Ready for networking with XML output.
By lifting up the device cover, the FRED PA-1 starts up immediately and guides the rescuer step-by-step during the entire resuscitation process. The FRED PA-1 is available either as semi-automatic or fully automatic device.In its automatic version,...
Unbelievably small and light mechanical chest compression device In case of a sudden cardiac arrest, immediate chest compressions are required. Performing manual chest compressions well for an extended period of time is almost impossible. Thanks to...