Search Tag: septic shock

Sepsis

Monotherapy-or-combination-therapy-for-septic-shock

2024 28 Feb

  International guidelines recommend using corticosteroids for adults with septic shock who require vasopressor therapy, supported by moderate-quality evidence. While corticosteroids may shorten the duration of shock, their impact on mortality remains uncertain. A recent meta-analysis found no significant reduction in mortality among septic shock...Read more

Sepsis

Hydrocortisone-plus-fludrocortisone-for-cap-related-septic-shock

2024 13 Feb

  In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortisone on patients with community-acquired pneumonia (CAP) compared to those with non-CAP-related septic shock. The goal was to determine whether glucocorticoids...Read more

Sepsis

International-consensus-criteria-for-paediatric-sepsis-and-septic-shock

2024 23 Jan

In 2017, an estimated 25 million children worldwide experienced sepsis, resulting in over 3 million deaths. Paediatric sepsis survivors often face ongoing physical, cognitive, emotional, and psychological challenges. Children, particularly in lower-resource settings, face a higher risk of developing sepsis during their early years. The World Health...Read more

Sepsis

Decoding-the-cytokine-storm-in-sepsis

2024 12 Jan

Sepsis is a prominent cause of mortality in ICUs. Despite extensive research on the dynamics leading to sepsis, the role of cytokines—immune system molecules that can cause substantial harm to the body—has remained inadequately understood. While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine...Read more

ICU Management

Cardiovascular-management-in-sepsis-improving-cardiac-and-vascular-functions

2023 13 Oct

Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management.     Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...Read more

ICU Management

World-sepsis-day-lets-work-together-to-encourage-and-support-sepsis-research

2023 12 Sep

A woman came to see me a few days ago: her 44-year-old husband recently died from sepsis in another hospital, and she wanted to have a discussion about this tragic story. Her husband had had just some kind of blister on his foot. He didn’t seem very ill when he arrived at the hospital, but he quickly developed an extended area of fasciitis on his left...Read more

Sepsis

Thiamine-for-renal-protection-in-septic-shock

2023 06 Sep

Kidney injury frequently occurs in patients with septic shock and is linked to worse clinical outcomes. Administering thiamine (vitamin B1) as part of a mitochondrial resuscitation strategy might help mitigate septic kidney injury.   Thiamine is crucial for aerobic respiration, and thiamine can lead to organ dysfunction. Because the kidney contains...Read more

Sepsis

Vasopressin-loading-for-refractory-septic-shock

2023 01 Aug

Vasopressin is a potent vasopressor used to treat septic shock, acting via a different receptor than catecholamines. Previous randomised control trials have demonstrated its efficacy. However, its use can also lead to adverse effects such as ischaemia events. Therefore, it is recommended as a second-line agent after noradrenaline.   Typically,...Read more

Sepsis

Influence-of-gender-on-age-associated-mortality-in-sepsis

2023 13 Jun

Despite advancements in medical care, sepsis remains a significant global health issue and a leading cause of hospital mortality worldwide. Numerous epidemiological studies have been conducted on sepsis, but its epidemiology remains unclear due to its heterogeneous nature.   Sepsis is characterised by an imbalanced immune response to infection....Read more

ICU Management

High-vs-low-mean-arterial-pressure-in-cirrhosis-patients

2023 09 May

A new study assessed the impact of high mean arterial pressure (MAP) on renal outcomes in critically ill cirrhosis patients with septic shock (CIC). The efficacy of a high MAP strategy (80-85 mm Hg; H-MAP) was compared to a low MAP strategy (60-65 mm Hg; L-MAP) in improving 28-day mortality in CIC. Additionally, the study examined the reversal of shock,...Read more

Sepsis

Personalising-fluid-therapy-in-septic-shock

2023 05 Apr

Volume expansion, the initial therapeutic measure for septic shock, involves the intravenous injection of a few hundred millilitres of fluid over a few minutes. However, using fluids in septic patients is a complex strategy, with various types of fluids available. The effects of fluid boluses are inconsistent and transient, and fluids carry risks,...Read more

Sepsis

Sequential-extracorporeal-therapy-in-sepsis

2023 15 Feb

Sepsis and septic shock are significant causes of morbidity and mortality in critical care, with a complex and rapidly evolving clinical presentation. This involves microbial invasion, infection focus, immune response, circulating pathogen and pathogen products, immunodysregulation, organ damage, and multiple organ dysfunction. Extracorporeal therapies...Read more

Sepsis

Remote-ischaemic-conditioning-in-septic-shock

2022 25 Oct

Septic shock is one of the most severe complications of any infection. It affects millions of people each year. Studies show that in the U.S. and Europe, nearly 10% of patients admitted to the ICU have septic shock. Significant efforts have been made to recognise and treat septic shock early. Still, over 50% of patients die of septic shock within days...Read more

Sepsis

Prehospital-bundle-of-care-associated-with-mortality-decrease-in-septic-shock

2022 11 Oct

Over 50 million people worldwide suffer from sepsis every year. Sepsis causes nearly 11 million deaths and is responsible for one-third to half of all in-hospital deaths. The mortality rate for sepsis ranges from 10 to 20%. For septic shock, the most serious form of sepsis, the mortality rate can range from 50 to 60%.  Guidelines recommend early...Read more

Sepsis

Source-control-and-sepsis-management

2022 27 Sep

Source control is important in the treatment of sepsis and septic shock. Lack or delay of source control can result in worse outcomes for patients.   The 2021 Surviving Sepsis Campaign guidelines recommend identifying the anatomical source of infection that requires source control and implementing it as soon as possible. However, adequate source...Read more

Sepsis

Icu-vs-high-dependency-care-unit-for-septic-shock

2022 26 Jul

Sepsis is a life-threatening disease with high mortality. More than 10,000 people die from sepsis every year in Japan. Septic shock is when sepsis is associated with circulatory and cellular metabolic abnormalities. International guidelines recommend the use of antimicrobial therapy and source control with drainage or surgery, intensive care with fluid...Read more

ICU Management

Sepsis-in-critical-care-3

2022 16 Mar

Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly  14 million adults and 2.5 million children  survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...Read more

ICU Management

Septic-shock-and-vasopressor-initiation-why-earlier-is-better

2022 16 Mar

An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Campaign...Read more

ICU Management

Challenges-in-the-haemodynamic-management-of-septic-shock

2022 16 Mar

An overview of the haemodynamic management of patients in septic shock and strategies for detection of haemodynamic changes and appropriate therapeutic action to improve the prognosis of these patients. Introduction Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ...Read more

ICU Management

Ed-admission-and-adherence-to-surviving-sepsis-campaign-bundle

2022 15 Feb

Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid...Read more

ICU Management

Intravenous-vitamin-c-administration-for-septic-shock

2022 01 Feb

Sepsis is a life threatening condition with an estimated 49 million cases worldwide and 11 million deaths. It involves organ dysfunction due to a dysregulated host response to infection. Sepsis continues to be a global health issue and is is responsible for approximately 20% of annual global deaths.   Sepsis is typically managed through intravenous...Read more

ICU Management

Outcome-after-intubation-for-septic-shock

2021 09 Nov

Acute respiratory failure in septic patients is associated with higher in-hospital mortality. Early management and treatment with antibiotics, fluids, vasopressors, and source control, can reduce morbidity and mortality. Sepsis-related acute respiratory failure is also frequent and may require non-invasive or invasive ventilator support.   While...Read more

ICU Management

Lives2021-high-dose-cpfa-in-septic-shock-patients-compact-2-trial

2021 05 Oct

Findings from the COMPACT-2 trial were presented today at #LIVES2020. The study evaluated the efficacy and safety of high dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic shock. The study was performed in 12 Italian ICUs and enrolled patients aged 14 or more who were admitted...Read more

ICU Management

Vasopressor-management-in-septic-shock-general-overview-and-personalised-approaches

2021 24 Jun

This article summarises the proceedings of an ESICM webinar in which two experts discuss vasopressor therapy and its fundamental role in the treatment of septic shock-induced hypotension. They provide an overview of severe septic shock, the benefits of second-line vasopressors and their use in COVID-19 patients. Vasopressors in Severe Septic...Read more

ICU Management

Culture-negative-and-culture-positive-sepsis-or-septic-shock

2021 19 May

Incidence of sepsis and septic shock has been increasing consistently, and the morbidity and mortality associated with this is an area of concern. Mortality from sepsis and septic shock is quite high, ranging between 20 to 40%. Guidelines for sepsis and septic shock recommend the application of broad-spectrum antibiotics. There is clinical evidence...Read more

ICU Management

Study-investigates-the-ability-of-masimo-o3-r-to-monitor-septic-shock-patients-predict-mortality

2021 05 May

Researchers Found That O3 May Help Clinicians Rapidly Assess Circulatory Status in Patients Experiencing Septic Shock and Have Prognostic Value in Mortality Prediction NEUCHATEL, Switzerland--(BUSINESS WIRE)--  Masimo  (NASDAQ: MASI) announced today the findings of a study published in the Journal of Anesthesia & Clinical Research in which Dr....Read more

ICU Management

Treatment-of-catecholamine-refractory-hypotension-in-septic-shock-beyond-first-line-vasopressor

2020 24 Nov

Hypotension during septic shock is a strong indicator of patient outcome and mortality. Arginine vasopressin is a naturally produced human hormone with vasoconstriction effect via V1 receptor activation and a short 5-20 minutes half-life and is recommended by the Surviving Sepsis Campaign guidelines to be added as a second-line vasoactive agent when...Read more