Search Tag: septic shock
2020 14 Sep
Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research...Read more
2020 03 Feb
Initial fluid resuscitation practices for patients with haemodynamic shock remain controversial. There is significant variability in these practices, and the impact of this is still poorly understood. Overall, non-patient-centred resuscitation practices, conflicting treatments, variability, and failure to meet targets for initial resuscitation are...Read more
2020 22 Jan
Sepsis is a life-threatening condition that causes nearly one-third to half of all hospital deaths. It is also responsible for more than 5 million deaths worldwide each year. Patients with septic shock are an important subgroup of sepsis. These patients have circulatory and metabolic abnormalities that further increase their mortality risk. New treatments...Read more
2019 28 Dec
As we move into 2020, here's a quick recap of our most clicked stories in ICU in 2019: Using Biomarkers for Mortality Prediction in Patients With Sepsis A new study evaluated the prognostic value of six biomarkers at onset of sepsis in adult patients with sepsis or septic shock. Risk Factors for Frailty and Death in the ICU...Read more
2019 01 Dec
Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these...Read more
2019 23 Nov
Sepsis has always carried high mortality. Even today, with all the latest technology and newer antibiotics, sepsis continues to be a major risk factor for death. It is important to understand that the earlier sepsis is diagnosed and treated, the better the prognosis. Each year, nearly 6 million people die of sepsis in the US. Because of its aggressive...Read more
2019 14 Nov
Over the last few years, many advances have been made in the critical care of patients with septic shock. Both diagnosis and treatment strategies have improved. However, the mortality rates of patients with septic shock have a bimodal distribution; some patients die within a few days from it, while others die a few weeks later from other comorbidities. ...Read more
2019 21 Oct
Sepsis is a major cause of death among hospitalised patients. It affects nearly 6% of all admissions and results in in-hospital mortality of greater than 15%. Early detection could reduce mortality, as it would result in the timely implementation of evidence-based interventions. Clinical researchers have developed and implemented a machine-learning...Read more
2019 03 Jun
On Day 2 of the Euroanaesthesia Congress 2019 (#EA19), there was a session on Resuscitation in septic shock: is less better? Three key speakers Gernot Marx (Aachen, Germany), Claude Martin (Marseille, France) and Jean-Louis Vincent (Brussels, Belgium), spoke about less fluid, less vasopressors and less inotropes in septic shock. The central message...Read more
2019 23 Apr
Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure. This article, published in the journal Critical Care, proposes the concept of “broad spectrum vasopressors”...Read more
2019 18 Mar
A Chinese research team performed a meta-analysis and trial sequential analysis of randomised controlled trials (RCTs) evaluating the effects of vasopressin receptor agonists in septic shock patients. Their findings show the use of vasopressin might result in reduced mortality in these patients, but an increased risk of digital ischaemia must be taken...Read more
2019 27 Feb
Among patients with septic shock, a resuscitation strategy targeting normalisation of capillary refill time, compared with a strategy targeting serum lactate levels, did not reduce all-cause 28-day mortality. These findings from the ANDROMEDA-SHOCK randomised clinical trial do not support the use of a peripheral perfusion-targeted resuscitation strategy...Read more
2018 16 Oct
In the past decades there have been significant advances in the diagnosis and management of patients with sepsis and septic shock, and overall awareness has increased significantly (Angus and van der Poll 2013). Emphasis is currently on the early detection of sepsis and rapid initiation of fluid administration and antibiotic therapy, all of which...Read more
2018 16 Oct
The latest in diagnosis and treatment. Sepsis is a life-threatening condition in children. Current paediatric definitions are based on systemic inflammatory response syndrome. Since the publication of the third international consensus definitions for sepsis and septic shock for adults, efforts in paediatrics are focused on finding a definition...Read more
2018 13 Sep
A state-wide mandated public reporting of compliance with protocols to treat severe sepsis and septic shock appears to improve care and reduce mortality, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. In "Mortality Changes Associated with Mandated Public...Read more
2017 22 Aug
In a new analysis, 57% of patients meeting old definition for septic shock did not meet Sepsis-3 criteria. Although Sepsis-3 criteria identified a group of patients with increased organ failure and higher mortality, those patients who met the old criteria and not Sepsis-3 criteria still demonstrated significant organ failure and 14% mortality rate....Read more
2017 13 Jun
According to a new study, the use of a multifaceted intervention including an electronic sepsis alert (e-alert) system with sepsis response team was associated with improvement in care processes of sepsis and septic shock and patient outcomes. The findings are reported in the journal Annals of Intensive Care. Although sepsis is a leading cause of...Read more
2017 22 May
Prompt antibiotic initiation is associated with improved mortality in sepsis and septic shock. However, new research shows that patients with sepsis, a life-threatening complication of an infection, had delays approaching one hour in being given antibiotics when seen in emergency rooms that were overcrowded. The findings were presented at the 2017...Read more
2017 17 Apr
A new study reported in the journal CHEST demonstrates the beneficial effects of high-dose intravenous vitamin C in reducing mortality in patients with severe sepsis. However, an Editorial published in the same issue of CHEST, calls for more studies to determine optimal dose of vitamin C in the critically ill population. See Also : Albumin Administration...Read more
2017 21 Mar
Patients with septic shock admitted to hospitals affected by the 2011 shortage of the drug norepinephrine had a higher risk of in-hospital death, according to a study presented at the 37th International Symposium on Intensive Care and Emergency Medicine. See Also : New Strategy for Identifying Sepsis Arising in the ICU The study, also published...Read more
2017 01 Mar
An Editorial in the journal Chest emphasises the need to develop highly accurate, flexible methods for identifying patients with septic shock to ensure these patients are appropriately treated and hospitals are reliably assessed for treating these patients. Sepsis is now the most costly hospital condition and the most common diagnosis among patients...Read more
2017 24 Jan
The Surviving Sepsis Campaign , an initiative of the Society of Critical Care Medicine, the European Society of Intensive Care Medicine and the International Sepsis Forum, has released the 2016 Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis and septic shock. The document, published simultaneously in Critical Care Medicine...Read more
2016 03 Oct
The results of the first randomised controlled trial investigating the effects of adjunctive early low-dose hydrocortisone to prevent progression to shock in patients with severe sepsis presenting without shock are published in JAMA today. There were no significant differences between treatment groups with regard to mortality or length of stay in...Read more
2016 27 Sep
A multicentre trial investigating early use of vasopressin compared to norepinephrine to treat septic shock found no reduction in the number of kidney failure-free days. The results of the VAsopressin vs. Noradrenaline as Initial therapy in Septic sHock (VANISH) trial are published in JAMA (Gordon et al. 2016). Patients who had septic...Read more
2016 09 Aug
A study was conducted to determine whether high dose intravenous sodium selenite treatment and procalcitonin-guided anti-infectious therapy in patients with severe sepsis affect mortality. The findings are published in JAMA Internal Medicine . Patients with severe sepsis suffer from oxidative stress that could contribute to multiorgan failure and...Read more
2015 07 Aug
Researchers at Johns Hopkins University have developed a new computer-based method that can help clinicians identify hospital patients at risk of septic shock. The method correctly predicts septic shock in 85 percent of cases, without increasing the false positive rate from screening methods that are currently used, according to a study published in...Read more
2015 04 Jan
A new study, published in BMC Medical Informatics and Decision Making, aimed to determine the diagnostic accuracy of an electronic alert system in detecting severe sepsis or septic shock in ED patients. The study was carried out at a tertiary academic medical centre in Saudi Arabia. The results showed high specificity and sensitivity and negative...Read more
2014 06 Nov
Most patients now survive a hospital stay for septic shock, although 23 percent of these patients will return to the hospital within 30 days, according to a new study. The number is noticeably higher than the normal readmission rate at a large academic medical centre, researchers reported. The study findings have been published in Critical Care Medicine...Read more