Search Tag: antibiotic resistance

Sepsis

Deaths-from-neonatal-sepsis-and-the-need-to-improve-treatment

2023 05 Jul

A global observational study jointly led by University College London (UCL) has revealed a concerning trend in the effectiveness of antibiotics to treat sepsis in newborn babies. The study, conducted across 19 hospitals in 11 countries and involving over 3,200 infants with sepsis, found a high mortality rate among infants with culture-positive sepsis...Read more

ICU Management

Antibiotic-resistance-3

2022 16 Nov

Moderator Jean-Louis Vincent  Editor-in-Chief  @ ICU Management & Practice Professor Department of Intensive Care Erasme Hospital Université libre de Bruxelles Brussels, Belgium Panellists Jan De Waele Full Professor Ghent University Jordi Rello Full Professor Universitat Internacional de  Catalunya...Read more

ICU Management

Antibiotic-resistance-1

2022 14 Oct

Infections occur frequently in critically ill patients in the ICU. They may be the reason for admission and could also be due to immunosuppression associated with critical illness. Antibiotics are essential tools for treating both common and complex infections. It is recommended that antibiotics should be administered as soon as possible once an infection...Read more

ICU Management

Antibiotic-resistance-2

2022 14 Oct

Antibiotic resistance is one of the most significant public health challenges today. Join our panellists as they discuss the problem of antibiotic resistance, its impact on patient outcomes, the importance of effective antimicrobial stewardship programmes, the role of rapid diagnostic testing, and important strategies to reduce the spread of antimicrobial...Read more

ICU Management

Antibiotic-review-kit-for-hospitals

2022 11 Oct

Antibiotic overuse is a growing problem in healthcare. Antimicrobial resistance has a significant impact on global public health, and its effects are similar to that of malaria and HIV. Antimicrobial resistance caused nearly 4.95 million deaths in 2019. In addition, antimicrobial resistance has significant economic consequences on healthcare systems. ...Read more

Executive Health Management

Why-is-the-pharmaceutical-industry-not-developing-new-antibiotics

2021 26 Nov

An overview of antibiotic resistance, causative factors, reasons for the lack of research and drug development in this area and potential solutions. Key Points Antibiotic resistance is one of the biggest threats to global health. The  primary  culprit of fuelling antibiotic resistance is the misuse and overuse of existing antibiotic...Read more

ICU Management

Timing-of-antibiotic-therapy-in-the-intensive-care-unit

2021 19 Oct

Severe infections are common among patients in the ICU. According to findings from the Extended Study on Prevalence of Infection in Intensive Care III (EPIC III), 54% of the study patients had at least one suspected or proven infection on the study day, and 24% of these patients had more than one suspected or proven infection.   These infections...Read more

ICU Management

Isicem21-advances-in-resistant-gram-negative-pneumonia

2021 03 Sep

In an interesting discussion at the 40th ISICEM International Symposium on Intensive Care & Emergency Medicine,  Richard Wunderink, Professor of Medicine, Pulmonary and Critical Care Division of Northwestern University’s Feinberg School of Medicine and Medical Director, Medical ICU, Northwestern Memorial Hospital, Chicago, discussed rising levels of...Read more

ICU Management

Covid-19-and-antimicrobial-stewardship

2020 19 Oct

COVID-19 is a new disease. On initial presentation, clinicians can find it difficult to differentiate between coronavirus disease and bacterial community-acquired pneumonia. COVID-19 patients often develop a hyperinflammatory phase during the disease process, which could again be difficult to distinguish from a secondary bacterial infection. That is...Read more

ICU Management

Biomarker-guided-antibiotic-stewardship-in-suspected-ventilator-associated-pneumonia

2019 15 Dec

Ventilator-associated pneumonia carries enormous morbidity and mortality, including prolonging hospital stay and increasing the cost of healthcare. In most cases, ventilator-associated pneumonia occurs without any specific signs or symptoms. Making an accurate diagnosis is often difficult. Unlike the past, the administration of empirical antibiotics...Read more

ICU Management

Antibiotic-timing-and-administration-in-the-ed

2019 01 May

Antibiotics are often prescribed in the emergency department (ED) to patients with suspected infection before any definitive diagnosis can be made. However, amidst increasing antibiotic resistance, their use should be limited to those at high risk of infection or further clinical deterioration. Current tools to aid clinical decision-making include...Read more

ICU Management

Results-of-the-abate-infection-trial

2019 14 Mar

According to results of the ABATE infection trial, daily bathing with an antiseptic soap, plus nasal ointment for patients with prior antibiotic-resistant bacteria reduced hospital-acquired infections among patients with central venous catheters and other devices.   The ABATE infection trial included 340,000 patients from 53 hospitals. The study...Read more

ICU Management

The-accelerate-pheno-system-in-clinical-practice-fast-and-accurate-turnaround-for-critical-results

2018 01 Jun

Our clinical experiences of using the Accelerate Pheno™ system have greatly benefited patient care, providing earlier diagnostic certainty. Two complex sepsis cases are discussed, where the impact of rapid identification, with antibiotic sensitivities, of the causative organism from blood cultures is described. At Hampshire Hospitals NHS...Read more

ICU Management

Should-empiric-antibiotic-therapy-be-considered-old-fashioned

2018 26 Mar

The Surviving Sepsis Campaign recommends starting empiric broad-spectrum antibiotics in the initial management of patients with severe sepsis and septic shock (Rhodes et al. 2017). As a consequence, many patients receive unnecessary antibiotics, exposing them to adverse events, while others might be undertreated in spite of broad-spectrum therapy...Read more

ICU Management

Sepsis-care-bundles-may-increase-antibiotic-resistance

2017 10 Oct

Previous research has shown the effectiveness of care bundles in the diagnosis and treatment of septic patients. However, a new study suggests such care protocols could lead to increased use of certain broad-spectrum antibiotics and healthcare facility-onset (HCFO) C. difficile infection (CDI) rates. The study, published in the American Journal of...Read more

Executive Health Management

Doing-the-right-thing-antibiotics-control

2016 16 Feb

A new study shows that behavioural interventions that target the competitive spirits and desire of doctors to strengthen their reputations can motivate them to reduce unnecessary antibiotic prescriptions. The study is published in The Journal of the American Medical Association.  Principal investigator and senior author Jason Doctor, Director of Health...Read more

ICU Management

European-congress-of-clinical-microbiology-and-infectious-diseases-2015-antibiotics

2015 07 Dec

The European Congress of Clinical Microbiology and Infectious Diseases , the annual meeting of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) is the most attended infectious disease conference worldwide. This year, more than 10,000 clinicians and scientists attended the congress to present and share the latest research...Read more

ICU Management

Multidrug-resistant-gram-negative-bacteria-in-hospitals-new-guidelines

2015 24 Nov

New guidelines on the prevention and control of multidrug-resistant Gram-negative bacteria in hospitals have been published by the Journal of Hospital Infection . These guidelines are accredited by the National Institute for Health and Care Excellence in the UK. Gram-negative bacteria (MDRGNB) include common types such as E. coli that are present...Read more

ICU Management

New-antibiotics-group-shows-promise-against-staph-mrsa

2015 15 Sep

Virginia Tech researchers say a new group of antibiotics shows potential in fighting the bacteria Staphylococcus aureus (staph) and the antibiotic-resistant strains commonly known as MRSA. The discovery, published in Medicinal Chemistry Communications , shows that the new antibiotics are unlike contemporary antibiotics because they contain iridium,...Read more

Executive Health Management

Stop-it-trial-shows-antibiotic-use-can-be-reduced

2015 12 Jun

According to researchers at the University of Virginia School of Medicine and 22 other institutions, the duration of antibiotic treatment for complicated abdominal infections can be cut by half and still remain effective. This could play an important role in preventing the development of antibiotic-resistant superbugs. The research team looked at...Read more

Executive Health Management

Microbiome-disruption-ups-sepsis-risk-in-hospitalised-patients

2015 04 Jun

A new University of Michigan and VA study shows that older adults are three times more likely to develop sepsis — a body-wide catastrophic response to infection — in the first three months after leaving a hospital than at any other time. Notably, the risk of sepsis is 70 percent higher for those who received care that is likely to alter the balance...Read more

Executive Health Management

New-chip-allows-optimal-antibiotic-selection

2015 31 May

Researchers at the University of Toronto have designed a diagnostic chip that can help reduce testing time for antibiotic resistance from days to one hour. This can enable doctors to select the right antibiotic from the very beginning. The work has been published in the journal Lab on a Chip. Antibiotic resistance is a serious issue. According to...Read more

Executive Health Management

Hospitals-not-making-enough-effort-to-prevent-c-difficile-infections

2015 29 Apr

According to a survey of a national random sample of hospitals, nearly half of American hospitals aren't taking the steps required to prevent a gut infection that kills nearly 30,000 people annually and sickens hundreds of thousands more. The survey was conducted by a team from the University of Michigan Medical School and VA Ann Arbor Healthcare...Read more

ICU Management

Personalised-treatment-for-cancer-patients-with-pneumonia

2015 14 Apr

A study by researchers from D'Or Institute for Research and Education (IDOR) in Brazil has analysed the factors associated with severe pneumonia in hospitalised cancer patients and suggests that more personalised treatment protocols can reduce mortality in these patients. The findings are published online in PLoS ONE . It is widely believed that the...Read more

Executive Health Management

Pressure-to-prescribe-more-antibiotics-ordered-where-physicians-compete-with-clinics

2015 25 Feb

Wealthier areas of the US have more antibiotic prescriptions written per capita, where there is greater competition among care providers, according to new research from Johns Hopkins. Patients in such areas may be more able and likely to shop for physicians who are willing to write a prescription. As a result, doctors’ offices compete with retail medical...Read more

ICU Management

Biomarker-predicts-burn-patients-risk-of-infection

2015 11 Feb

A Massachusetts General Hospital (MGH)-led study has shown that a set of characteristics, including differences in gene expression, may indicate which patients recovering from severe burns are at greatest risk for repeat infections. The finding is published online in Annals of Surgery . "Our approach is the first to enable the prediction of repeat...Read more

ICU Management

Study-protocol-increases-appropriate-antibiotic-use

2015 19 Jan

According to a retrospective study, an antibiotic protocol that determined antibiotic use based on risk for health care-associated infections significantly increased appropriate prescription of antibiotics in a paediatric ICU. The study has been published online in Annals of the American Thoracic Society .   Researchers evaluated patients with an...Read more

Pharmacy Management

New-antibiotic-teixobactin-could-be-a-game-changer

2015 10 Jan

A novel method for growing bacteria has finally yielded a promising new antibiotic which could be a major breakthrough ending a decades-long drought in antibiotic discovery. The last new class of antibiotics was discovered nearly three decades ago. During this time, microbes have become more and more resistant. However, a new study published...Read more

ICU Management

New-software-predicts-superbugs-countermoves-to-new-drugs

2015 05 Jan

In the fight against drug-resistant bacteria, new drugs are urgently needed, but so are ways to maximise the effective lifespan of these drugs. Researchers at Duke University in the U.S. have developed open-source software that can predict a constantly-evolving infectious bacterium's counter-moves to a new drug before the drug is tested on patients....Read more