Search Tag: adaptive clinical trials

ICU Management

Sepsis Clinical Trials - Can Do Better?

2016 05 Apr

Mortality from sepsis remains high, and results of clinical trials have been disappointing. Changing trials design has the potential to improve treatment, according to leading experts in sepsis and acute heart failure. The results of their discussions, which were facilitated by the European Drug Development, are published in the Journal of Intensive... Read more

ICU Management

Adaptive Clinical Trials - the Ethical View

2015 12 May

Adaptive clinical trials (ACTs) represent an innovative approach to trial design and conduct, where the primary goal of adaptations is to improve scientific value and statistical efficiency. In addition to having distinguishing scientific features, ACTs also may involve ethical considerations that differ from more traditional randomised controlled trials... Read more


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