Search Tag: Sepsis
Clinical-predictors-of-early-death-from-sepsis
2017 04 Jul
Patients with severe sepsis who experience rapid, early deterioration and death are of particular concern. However, given the broad spectrum of clinical presentations and variable rates of disease progression, the early identification of septic patients at increased risk for clinical deterioration remains challenging. New research indicates that initial...Read more
Poc-device-can-test-for-sepsis-from-drop-of-blood
2017 03 Jul
Researchers from the University of Illinois and Carle Foundation Hospital in Urbana, Illinois, USA, have developed a new portable device, which they say is the first to provide rapid, point-of-care measurement of the immune system's response, without any need to process the blood. You might also like : New Biomarker Improves Early Sepsis Detection...Read more
New-biomarker-improves-early-sepsis-detection-in-the-ed
2017 27 Jun
Sepsis most often presents to the emergency department (ED), and delayed detection is harmful. The white blood count (WBC) is often used to detect sepsis in the ED. New research shows that volume increases of circulating immune cells, or monocytes, adds value to the WBC for early sepsis detection in the ED. "This study shows that the monocyte distribution...Read more
The-rusty-and-sweet-side-of-sepsis
2017 21 Jun
Sepis affects approximately 18 million people worldwide per year. This corresponds to 1400 deaths per day. It is estimated that sepsis is the cause behind 135,000 and 215,000 casualties in Europe and the U.S. respectively. Related treatment costs accumulate to €7.6 and €17.4 billion in these regions. A research team led by Miguel Soares at...Read more
Sepsis-e-alert-system-with-response-team-improves-outcomes
2017 13 Jun
According to a new study, the use of a multifaceted intervention including an electronic sepsis alert (e-alert) system with sepsis response team was associated with improvement in care processes of sepsis and septic shock and patient outcomes. The findings are reported in the journal Annals of Intensive Care. Although sepsis is a leading cause of...Read more
New-protocol-improves-sepsis-detection-in-children
2017 12 Jun
Sepsis, a life-threatening condition, is difficult to identify accurately in children. Researchers in the U.S. have developed a two-stage electronic sepsis alert (ESA) to improve detection of paediatric severe sepsis in the emergency department. Using a combination of vital signs, risk factors and physician judgment, the ESA reduces missed sepsis diagnoses...Read more
Antibiotics-for-sepsis-does-each-hour-really-count
2017 31 May
"Each hour’s delay in initiating antibiotics costs lives" is a doctrine that has attained quasi-religious status. Like most (quasi-)religions this is founded more on faith and hope than hard fact, according to an article in press in the American Journal of Respiratory and Critical Care Medicine. Article author Mervyn Singer, Professor of Intensive...Read more
Sepsis-detection-and-management-new-klas-report
2017 28 May
Healthcare providers are increasingly turning to technology to detect sepsis and report on sepsis management. As most electronic medical record (EMR) providers do not offer easily deployed sepsis modules, healthcare providers report using solutions from infection control and surveillance vendors as well as specialised sepsis solutions. KLAS Research’s...Read more
Ats-2017-machine-learning-may-help-to-identify-sepsis-early
2017 24 May
Using electronic health records (EHRs) to identify patients in hospital at risk for sepsis is now possible using machine learning. Machine learning does not rely on rules, but is able to learn complex patterns in data without being programmed to do so. Researchers from the University of Pennsylvania Health System presented their study of a machine-learning...Read more
Er-overcrowding-delays-sepsis-treatment
2017 22 May
Prompt antibiotic initiation is associated with improved mortality in sepsis and septic shock. However, new research shows that patients with sepsis, a life-threatening complication of an infection, had delays approaching one hour in being given antibiotics when seen in emergency rooms that were overcrowded. The findings were presented at the 2017...Read more
Sepsis-survivors-experience-lingering-effects
2017 05 May
New research to be presented at the 2017 Pediatric Academic Societies Meeting shows that despite the fact that survival rates among children who develop sepsis have risen dramatically in recent years, recovery still remains a long haul for these patients. Many of them continue to feel the physical, social and emotional effects long after they are...Read more
Vitamin-c-in-severe-sepsis-treatment
2017 17 Apr
A new study reported in the journal CHEST demonstrates the beneficial effects of high-dose intravenous vitamin C in reducing mortality in patients with severe sepsis. However, an Editorial published in the same issue of CHEST, calls for more studies to determine optimal dose of vitamin C in the critically ill population. See Also : Albumin Administration...Read more
Sepsis-associated-in-hospital-cardiac-arrest
2017 11 Apr
Sepsis-associated cardiac arrest is a relatively common occurrence with especially poor outcomes. A review paper, published in Journal of Critical Care, discusses the epidemiology of sepsis-associated in-hospital cardiac arrest in adults and children, the relevant physiology responsible for its pathogenesis and poor outcomes, and potential therapeutic...Read more
Fda-clears-test-to-help-manage-antibiotic-treatment-for-lower-respiratory-tract-infections-sepsis
2017 22 Mar
The U.S. Food and Drug Administration today cleared the expanded use of the Vidas Brahms PCT Assay to help health care providers determine if antibiotic treatment should be started or stopped in patients with lower respiratory tract infections, such as community-acquired pneumonia, and stopped in patients with sepsis. This is the first test to use...Read more
Precision-medicine-in-sepsis
2017 16 Mar
Multiple failed clinical trials testing immunomodulatory therapies for sepsis argue for a new approach. While precision medicine has been successfully implemented in other fields, testing it in sepsis poses challenges, which this review will discuss, along with potential implementation strategies. Sepsis has an estimated annual incidence of 1.3...Read more
The-importance-of-correctly-identifying-patients-with-sepsis
2017 01 Mar
An Editorial in the journal Chest emphasises the need to develop highly accurate, flexible methods for identifying patients with septic shock to ensure these patients are appropriately treated and hospitals are reliably assessed for treating these patients. Sepsis is now the most costly hospital condition and the most common diagnosis among patients...Read more
New-strategy-for-identifying-sepsis-arising-in-the-icu
2017 14 Feb
A new methodology using administrative codes coupled to a SIRS screening protocol can help identify patients whose sepsis initially appears during their ICU stay, with up to 94 percent accuracy, according to a new study published in Journal of Critical Care. See Also : Surviving Sepsis Guidelines 2016 Update "We found that we could reliably...Read more
Webinar-surviving-sepsis-guidelines-2016-what-do-you-need-to-know
2017 16 Feb
To follow the recent publication of the Surviving Sepsis Campaign’s (SSC) updated guidelines 2016 in Intensive Care Medicine ESICM will also organise an interactive Webinar "Surviving Sepsis Guidelines 2016: What do you need to know?" hosted by ESICM President Massimo Antonelli (Moderator) and SSC Co-Chair Andrew Rhodes (Presenter). This webinar...Read more
1-in-7-sepsis-patients-readmitted-within-30-days
2017 22 Jan
Readmissions due to sepsis are higher and costlier than for the four conditions already reported in the U.S. to measure quality of care and guide pay for performance, according to researchers from the University of Pittsburgh School of Medicine and VA Pittsburgh Healthcare System. Their research is published in JAMA to coincide with the presentation...Read more
Study-sofa-score-helps-predict-icu-mortality
2017 17 Jan
Among adults with suspected infection admitted to an ICU, an increase in Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 or more had greater prognostic accuracy for in-hospital mortality than the quick SOFA (qSOFA) score or the systemic inflammatory response syndrome (SIRS) criteria. The findings, published in JAMA , suggest...Read more
Promoting-venous-return-why-stressed-volume-matters
2016 07 Nov
An intimate understanding of stressed and unstressed volume is “vital to managing hypotension in the emergency department”, according to Rory Spiegel, Department of Emergency Medicine, Stony Brook Medicine, USA, writing in Clinical and Experimental Emergency Medicine . Spiegel describes mean systemic pressure (Pms) as an elusive concept that does...Read more
Optimizing-sepsis-management-in-the-intensive-care-unit-an-interview-with-jordi-trafi
2016 18 Oct
“Studies continue to show that guiding antibiotic therapy based on the dynamics of PCT levels in the blood will reduce not only the use of antibiotics but also the length of stay, hereby lowering hospital costs significantly" - an interview with Jordi Trafi. Sepsis can easily escalate to the life-threatening condition septic shock which has...Read more
Hydrocortisone-in-severe-sepsis-hypress-trial-results
2016 03 Oct
The results of the first randomised controlled trial investigating the effects of adjunctive early low-dose hydrocortisone to prevent progression to shock in patients with severe sepsis presenting without shock are published in JAMA today. There were no significant differences between treatment groups with regard to mortality or length of stay in...Read more
Vasoactive-drugs-in-sepsis
2016 27 Sep
In this update review on vasoactive drugs in sepsis, we focus on the most recent data regarding the type of vasopressors that should be used, the timing of infusion, the mean arterial pressure target and the alternative approaches. Sepsis and especially septic shock is associated with arterial vasodilation refractory to fluid challenge. The...Read more