Search Tag: Sepsis

ICU Management

The sepsis box, bag and trolley

2018 16 Oct

Evaluation of aids to the delivery of sepsis treatment. In NHS Wales the Sepsis 6 bundle, delivered within one hour of sepsis recognition, has been standard treatment in acute hospital settings since 2013. We describe various methods for increasing the speed and effectiveness of Sepsis 6 bundle delivery that have been trialled with positive... Read more

ICU Management

Practical steps to reduce the global burden of sepsis

2018 03 Oct

Sepsis is a major contributor to the global burden of disease. However, there are important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings; thus context-specific approaches are necessary to mitigate this major public health problem, according to a review published... Read more

ICU Management

Need for a patient-tailored approach in sepsis treatment

2018 26 Sep

Despite decades of sepsis research into a specific immune system-targeting adjunctive therapy, not a single adjunctive treatment is used in current clinical practice. Notably, in recent years, increased appreciation of the importance of sepsis-induced immunoparalysis in causing morbidity and mortality in sepsis patients has resulted in a paradigm... Read more

ICU Management

#EuSEM18: Sepsis in the emergency department - what antibiotics?

2018 18 Sep

Doctors are responsible for reducing antibiotic usage in their hospital, region and country. At the same time, emergency medicine doctors have the responsibility to treat very sick patients - with suspected sepsis and septic shock, efficiently. This was the conundrum addressed by Christian Backer Mogensen, consultant in infectious medicine and emergency... Read more

ICU Management

Sepsis process and outcomes improvement associated with mandatory reporting

2018 13 Sep

A state-wide mandated public reporting of compliance with protocols to treat severe sepsis and septic shock appears to improve care and reduce mortality, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. In "Mortality Changes Associated with Mandated Public... Read more

ICU Management

#EUSEM18: Sepsis in the over 70s presents differently

2018 13 Sep

Patients over 70 who present to the emergency department with sepsis have a higher disease severity, and therefore different risk stratification is needed, says Bas De Groot, Leiden University Medical Centre. He presented his recommendations at the European Society of Emergency Medicine annual congress, which met in Glasgow this week.    Their... Read more

ICU Management

Improving antibiotic initiation for sepsis, pre-hospital

2018 13 Sep

Sepsis is a common and costly condition encountered by pre-hospital and emergency department (ED) clinicians. Early antibiotics improve outcomes for septic patients. Researchers from Intermountain Medical Center in Utah led a study to investigate the relationship between septic patients’ pre-hospital level of care and ED door-to-antibiotic time. ... Read more

ICU Management

Septic cardiomyopathy - improving diagnosis and treatment

2018 06 Sep

Septic cardiomyopathy is a key feature of sepsis-associated cardiovascular failure. However, the lack of a clear and consistent definition of septic cardiomyopathy complicates not only the diagnosis but also the investigations of the prevalence of septic cardiomyopathy, according to a review to appear in the journal CHEST. Septic cardiomyopathy,... Read more

ICU Management

High ICU occupancy influences patient disposition from the ED

2018 29 Aug

Patients with sepsis not requiring life support therapies have a reduced likelihood of being admitted from the emergency department (ED) to the intensive care unit (ICU) when the ICU is crowded, according to new research led by the University of Pennsylvania Perelman School of Medicine. The study is in press in the journal Annals of the American... Read more

ICU Management

Understanding the role of haematopoietic growth factors in sepsis

2018 04 Jul

Sepsis is a complex syndrome characterised by simultaneous activation of pro- and anti-inflammatory processes. During sepsis, immune cells undergo profound phenotypic modifications in their activation state, response to stimuli, localisation, and numbers. These phenomena are finely regulated by various cytokines and haematopoietic growth factors... Read more