Search Tag: Sepsis

ICU Management

Risk of sepsis: does DNA matter?

2019 30 Jan

A new analysis has identified several genetic variants that could influence one's susceptibility to sepsis, a life-threatening condition. This study provides a novel insight that may affect personalised targeted treatment in the future clinical management of sepsis.  Variants are alterations in nucleotide base pairs located within a gene or... Read more

ICU Management

Sepsis 2019

2019 09 May

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ICU Management

University of Pittsburgh Medical Center: Spotlight on Sepsis

2018 30 Dec

In 2015, UPMC a global multi-hospital system that has over 40 hospitals and 85,000 employees, began a new sepsis initiative to increase the speed of identification and treatment of sepsis patients. According to the CDC, sepsis is a major cause of preventable patient deaths in hospitals. It’s estimated one in three patients who die in hospitals... Read more

ICU Management

Early IV fluid treatment and sepsis mortality

2018 18 Dec

Intravenous (IV) fluids provided by paramedics were associated with reduced in-hospital mortality for patients with sepsis and hypotension but not for those with a higher initial systolic blood pressure. This is the central finding of a large cohort study (n = 1,871 patients) conducted in Canada and published by JAMA Network.  Early IV fluid... Read more

ICU Management

Study: sepsis-induced DIC associated with high mortality

2018 27 Nov

Researchers in Japan conducted a multicentre retrospective observational study to investigate the epidemiology of disseminated intravascular coagulation (DIC) in patients with sepsis. They found that patients with DIC diagnosed by two consensus criteria had higher severity and in-hospital mortality than patients without DIC. The study results confirm... Read more

ICU Management

Metabolic-based biomarkers have potential to triage children with sepsis

2018 14 Nov

A new study has validated potential biomarkers for a sepsis-triage model to distinguish sepsis patients requiring care in the paediatric intensive care unit (PICU) from sepsis identified in the paediatric emergency department (PED) that does not require ICU admission. The study, led by Beata Mickiewicz and colleagues from the University of Calgary... Read more

ICU Management

'AI Clinician' can aid doctors in treating sepsis patients

2018 31 Oct

Researchers from Imperial College London have created an artificial intelligence system that could help treat patients with sepsis. Aptly named AI Clinician, the system could predict the best treatment strategy for patients. Tests conducted by the researchers showed that 98 percent of the time, the AI system matched or was better than the human... Read more

ICU Management

Extracorporeal techniques in sepsis treatment: benefits and risks

2018 31 Oct

Sepsis, a leading cause of morbidity and mortality worldwide, is characterised by a dysregulated immune response to infections that results in life-threatening organ dysfunction. Conventional therapy of sepsis typically starts with resuscitative measures; however, the only definitive therapy is adequate antibiotics and source control in surgical... Read more

ICU Management

Patients with AKI and sepsis: when to initiate renal-replacement therapy

2018 17 Oct

Among patients with septic shock who had severe acute kidney injury (AKI), there was no significant difference in overall mortality at 90 days between patients who were assigned to an early strategy for the initiation of renal-replacement therapy and those who were assigned to a delayed strategy, according to a randomised controlled trial published... Read more

ICU Management

Stronger evidence for vitamin C use in sepsis treatment

2018 17 Oct

A new meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favourable patient outcomes. Results of the meta-analysis showed a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C, despite varying degrees of statistical significance between... Read more