Search Tag: Sepsis

ICU Management

Vitamin C Drug Cocktail for Sepsis

2019 09 Jul

The combination of intravenous vitamin C, corticosteroids and thiamine has been made famous by Dr. Paul Marik, M.D. for the treatment of sepsis in critically ill patients. The ‘Marik protocol’, also termed HAT (Hydrocortisone, Ascorbic acid, Thiamine), has however come under criticism regarding the lack of evidence. Dr. Marik of Sentara Norfolk... Read more

ICU Management

Promising Ideas for Future Intensive Care

2019 26 Jun

The path to innovation is often based on intuition or insight. But the implementation of new ideas in healthcare requires rigorous testing and confirmation.  However, one can argue that in the field of critical care, this cautious approach has let clinicians down. There is no doubt that clinical trials are important, but at the same time, they... Read more

ICU Management

In-hospital mortality and misdiagnosis of site of infection

2019 11 Jun

Sepsis is one of the most dangerous and life-threatening conditions encountered in the intensive care unit. Sepsis is considered to be an emergent disease similar to trauma, heart attack, and stroke. But sepsis is characterised by various aetiologies and pathophysiological conditions, and that is why it is very complicated to treat compared to... Read more

ICU Management

Big Data and hidden subtypes of sepsis

2019 30 May

Results of a study conducted by the University of Pittsburgh School of Medicine suggests that sepsis is not one condition, but many conditions that could benefit from different treatments. The findings are published in JAMA and were presented at the American Thoracic Society's Annual Meeting.   Sepsis is the number one killer of hospitalised patients... Read more

ICU Management

Treatment implications of novel clinical phenotypes for sepsis

2019 23 May

Sepsis affects millions of individuals every year. It carries a high risk of death, even if prompt care is provided.  It has been decades, and no new therapies for sepsis have been discovered. A major barrier to progress in this area has been the overly broad definition for this syndrome. Sepsis has a vast array of clinical and biological features,... Read more

ICU Management

Immunotherapy effects on sepsis

2019 01 May

A randomised controlled multicentre trial assessed for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 (anti–PD-L1) immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb, Princeton, NJ) and its effect on immune biomarkers in participants with sepsis-associated immunosuppression. Results show that... Read more

ICU Management

New approach in managing patients with septic shock

2019 23 Apr

Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure.  This article, published in the journal Critical Care, proposes the concept of “broad spectrum vasopressors”... Read more

ICU Management

Study: obesity improves short-term survival in sepsis

2019 16 Apr

In a large cohort study of 55,038 adults hospitalised with sepsis, short-term mortality (death or hospice) was lower in overweight and obese patients compared with those with normal body mass indices (both unadjusted and adjusted analyses). These findings highlight the need for well-conducted prospective clinical trials that assess obesity’s impact... Read more