Search Tag: Sepsis
2023 22 Aug
In December 2017, angiotensin II (ATII) intravenous infusion gained approval in the U.S. for treating septic or other distributive shock in adults. This approval was based on results from a phase II clinical trial which showed higher mean arterial pressure in septic shock patients on norepinephrine, who were randomly assigned to titrated ATII compared...Read more
2023 01 Aug
Computer-based technologies, including artificial intelligence (AI) applications like ChatGPT and DALL-E, are being increasingly used and can mimic human capabilities, even passing medical board examinations. Retrospective studies have shown that machine learning (ML) applications are especially valuable in the ICU due to their diagnostic and prognostic...Read more
2023 01 Aug
Computer-based technologies, including artificial intelligence (AI) applications like ChatGPT and DALL-E, are being increasingly used and can mimic human capabilities, even passing medical board examinations. Retrospective studies have shown that machine learning (ML) applications are especially valuable in the ICU due to their diagnostic and prognostic...Read more
2023 01 Aug
Vasopressin is a potent vasopressor used to treat septic shock, acting via a different receptor than catecholamines. Previous randomised control trials have demonstrated its efficacy. However, its use can also lead to adverse effects such as ischaemia events. Therefore, it is recommended as a second-line agent after noradrenaline. Typically,...Read more
2023 06 Dec
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2023 24 Jul
Researchers from the Medical University of South Carolina (MUSC) have identified a novel biomarker that could revolutionise sepsis treatment. Sepsis, a life-threatening condition triggered by the body's extreme response to infection, is a leading cause of death in ICUs, often resulting in organ damage and failure. In a recent study published...Read more
2023 18 Jul
Sepsis is a frequently encountered condition that leads to severe illness and is associated with significant morbidity and mortality. It is commonly accompanied by acute kidney injury (AKI), known as sepsis-associated acute kidney injury (SA-AKI). The relationship between sepsis and AKI has been investigated in prior studies. However, the absence...Read more
2023 05 Jul
A global observational study jointly led by University College London (UCL) has revealed a concerning trend in the effectiveness of antibiotics to treat sepsis in newborn babies. The study, conducted across 19 hospitals in 11 countries and involving over 3,200 infants with sepsis, found a high mortality rate among infants with culture-positive sepsis...Read more
2023 28 Jun
Endotoxin can trigger immune responses and organ failure in sepsis patients. Polymyxin B hemadsorption (PMX-HA) is an extracorporeal blood purification technique to remove circulating endotoxin and prevent organ failure. While some studies have suggested that PMX-HA improves outcomes in sepsis patients, conflicting results have been observed in randomised...Read more
2023 13 Jun
Rapid Diagnostic Test that could save millions of lives At Swiss Medtech Day, the most important event in the Swiss medical technology industry with around 700 attendees, Lausanne-based company Abionic, founded in 2010, was presented with the Swiss Medtech Award valued at CHF 75,000. Abionic specialises in providing rapid diagnostic tests...Read more
2023 13 Jun
Despite advancements in medical care, sepsis remains a significant global health issue and a leading cause of hospital mortality worldwide. Numerous epidemiological studies have been conducted on sepsis, but its epidemiology remains unclear due to its heterogeneous nature. Sepsis is characterised by an imbalanced immune response to infection....Read more
2023 16 May
The 8th Central European Emergency Medicine Congress (CEEM 2023) organized by the Polish Society for Emergency Medicine was held in Bydgoszcz, Poland. The Congress offered a diverse range of lectures, workshops, and practical sessions delivered by world-renowned experts from Poland and abroad. The event was an opportunity for medical professionals...Read more
2023 09 May
Sepsis is characterised by a dysregulated host response to infection resulting in organ dysfunction. It poses a significant global health problem, with a high mortality risk and millions of patients affected annually. Epidemiological studies have shown that nearly 20% of septic patients require mechanical ventilation, leading to significant healthcare...Read more
2023 02 May
Sepsis is a major challenge in intensive care medicine with high morbidity and mortality. Early and proper use of antibiotics is crucial for effective treatment. Personalising antibiotic dosing is essential. However, maintaining adequate antibiotic exposure can be challenging, particularly for critically ill patients, as changes in organ function...Read more
2023 02 May
Dr François Ventura, anaesthesiologist and intensive care physician, gave a lecture on the " C urrent research on sepsis biomarkers and early diagnosis" during the 4th World Sepsis Congress, organised by the Global Sepsis Alliance, which took place the 25 th and 26 th April 2023. He discussed the challenges of diagnosing sepsis, which requires...Read more
2023 20 Apr
The International Symposium on Intensive Care and Emergency Medicine (ISICEM) is a renowned event in the medical industry, bringing together professionals from all over the world to discuss the latest developments and advancements in critical care and emergency medicine. This year's event took place from 21 to 24 April 2023 in Brussels. One...Read more
2023 13 Apr
Aferetica held the 3 rd "Purification Therapies" Workshop in Milano from September 30 th to October 1st. The event involved more than 400 participants from all over Europe to discuss on different critical care topics and in particular on overwhelming inflammatory diseases. One of the many sessions focused on the diagnostic side of the overwhelming...Read more
2023 05 Apr
Volume expansion, the initial therapeutic measure for septic shock, involves the intravenous injection of a few hundred millilitres of fluid over a few minutes. However, using fluids in septic patients is a complex strategy, with various types of fluids available. The effects of fluid boluses are inconsistent and transient, and fluids carry risks,...Read more
2023 15 Mar
Sepsis is a complex and dysregulated state involving various factors, including pathogens, host response, organ failure, and medical interventions. Despite this complexity, the necessary concepts, approaches, and methods to understand sepsis are underappreciated. In a recent review, the authors highlight the need to understand sepsis through...Read more
2023 13 Mar
This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for Biomarkers in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated...Read more
2023 13 Mar
A biomarker defines a measurable indicator of a patient's medical situation that can be measured precisely and accurately. Biomarkers provide value for diagnosis, prognosis, early disease detection, risk stratification, suitable treatment (theragnostic), and trial improvement for patients with sepsis or presumed sepsis. Introduction...Read more
2023 13 Mar
An overview of tachycardia in sepsis, the importance of rate control and the beneficial effects of beta-blockers. Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes...Read more
2023 13 Mar
An overview of tachycardia in sepsis, the importance of rate control and the beneficial effects of beta-blockers. Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes...Read more
2023 07 Mar
Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes...Read more
2023 15 Feb
Sepsis and septic shock are significant causes of morbidity and mortality in critical care, with a complex and rapidly evolving clinical presentation. This involves microbial invasion, infection focus, immune response, circulating pathogen and pathogen products, immunodysregulation, organ damage, and multiple organ dysfunction. Extracorporeal therapies...Read more