Search Tag: Sepsis
Vascular-leak-in-sepsis
2024 26 Mar
Sepsis remains a major cause of mortality, accounting for nearly 20% of global deaths. Microcirculatory dysfunction, marked by irregular blood flow and increased permeability of blood vessels, is a characteristic feature of sepsis. This dysfunction can lead to tissue swelling and impaired organ function. Endothelial dysfunction, which is also seen...Read more
Host-gene-expression-signatures-in-children-evaluated-for-sepsis
2024 19 Mar
Findings presented at #ISICEM24 show that novel host transcriptomic signatures specific for bacterial and viral infection in children evaluated for sepsis can identify dysregulated host response leading to organ dysfunction. The goal of the study was to create gene expression signatures in children with bacterial or viral infections to predict...Read more
Introduction-to-landiolol-in-acute-cardiac-care
2024 12 Mar
An overview of landiolol, a potent and cardioselective beta-blocker offering a promising addition to the armamentarium for managing acute cardiac conditions for rapid and effective rate control with minimal adverse effects. Cardiac emergencies present complex challenges in emergency medical settings, requiring prompt and effective management...Read more
Informative-subtyping-targeted-immunomodulatory-therapies-for-sepsis
2024 28 Feb
Sepsis is characterised by dysregulated immune responses. Traditional approaches to treating sepsis by targeting proinflammatory and immunosuppressive responses have been largely unsuccessful. Recent efforts have shifted towards identifying subtypes of sepsis to enable personalised treatment. However, many important immunological concepts, such...Read more
Qsofa-with-supar-for-risk-detection-antibiotic-treatment-guidance
2024 13 Feb
Early recognition and initiation of antibiotics are crucial in managing sepsis. Various warning scores, including qSOFA (quick Sequential Organ Failure Assessment), have been introduced to aid early detection. Patients with suspected infection and at least two of the qSOFA clinical signs are at a significantly higher risk of death after 28 days....Read more
Hydrocortisone-plus-fludrocortisone-for-cap-related-septic-shock
2024 13 Feb
In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortisone on patients with community-acquired pneumonia (CAP) compared to those with non-CAP-related septic shock. The goal was to determine whether glucocorticoids...Read more
Ai-surveillance-tool-to-predict-sepsis
2024 08 Feb
Nearly 1.7 million adults in the United States contract sepsis annually, with approximately 350,000 succumbing to the condition. In a recent study published in npj Digital Medicine, experts from the University of California San Diego School of Medicine harnessed an artificial intelligence (AI) model within the emergency departments of UC...Read more
Temporal-trends-in-mortality-of-patients-with-sepsis
2024 30 Jan
Sepsis, characterised by severe organ dysfunction, is a major cause of hospitalisation and mortality globally. The WHO recognises sepsis as a significant global health concern, urging efforts to enhance outcomes for affected individuals. Despite no new targeted therapies emerging for sepsis in recent decades, advancements in ICU management, shifts...Read more
Key-updates-including-epv-for-managing-sepsis-and-septic-shock
2024 20 Mar
Session One March 20, 2024 | 3:00 PM EST Session Two March 28, 2024 | 1:00 PM EST Session Three March 26, 2024 | 11:00 AM GMT Read more
International-consensus-criteria-for-paediatric-sepsis-and-septic-shock
2024 23 Jan
In 2017, an estimated 25 million children worldwide experienced sepsis, resulting in over 3 million deaths. Paediatric sepsis survivors often face ongoing physical, cognitive, emotional, and psychological challenges. Children, particularly in lower-resource settings, face a higher risk of developing sepsis during their early years. The World Health...Read more
English-proficiency-and-sepsis-mortality
2024 16 Jan
Sepsis is a leading cause of hospital deaths. Despite initiatives like the Surviving Sepsis Campaign and Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Management Bundle (SEP-1), healthcare disparities persist. Previous studies revealed disparities in sepsis outcomes by age, sex, race, and ethnicity, but limited English proficiency...Read more
Decoding-the-cytokine-storm-in-sepsis
2024 12 Jan
Sepsis is a prominent cause of mortality in ICUs. Despite extensive research on the dynamics leading to sepsis, the role of cytokines—immune system molecules that can cause substantial harm to the body—has remained inadequately understood. While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine...Read more
Return-to-work-after-hospitalisation-for-sepsis
2024 03 Jan
This study focuses on the impact of sepsis, a condition resulting from a dysregulated immune response to infection, on the ability of patients to return to work (RTW). Sepsis is a significant global health concern, causing substantial morbidity and mortality. Sepsis survivors commonly experience long-term cognitive and functional impairments, but the...Read more
Treating-the-whole-human-in-intensive-care-patient-centred-outcomes-in-sepsis-surgery-and-trauma
2023 30 Nov
Intensive care impacts more than the patient, with ripple effects for families, employers and wider societies. Patient-centred outcomes reiterate the need for clinical therapies targeting the biological circuitry of the big-hitting syndromes like ARDS, sepsis, delirium, renal failure and recognising they persist beyond the veil of discharge....Read more
Cardiovascular-management-in-septic-shock-optimising-vascular-and-cardiac-function
2023 30 Nov
An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia. Optimising Vasopressin Initiation in Septic Shock Patients with septic shock, and especially...Read more
Cardiovascular-management-in-septic-shock-optimising-vascular-and-cardiac-function
2023 30 Nov
An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia. Optimising Vasopressin Initiation in Septic Shock Patients with septic shock, and especially...Read more
Knowledge-and-awareness-of-sepsis-among-risk-populations
2023 22 Nov
Sepsis can have potentially life-threatening consequences. Early recognition is crucial for effective intervention. The role of patients in preventing and identifying sepsis early is vital. However, there is an incomplete understanding of sepsis knowledge among at-risk groups and their ability to recognise sepsis as a medical emergency. COVID-19...Read more
Uncovering-heterogeneity-in-sepsis
2023 08 Nov
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite progress in understanding its underlying mechanisms, there's no specific successful treatment for sepsis. Precision therapy is needed, and understanding the heterogeneity of sepsis is crucial. Recent methods have attempted to measure sepsis heterogeneity...Read more
Cardiovascular-management-in-sepsis-improving-cardiac-and-vascular-functions
2023 13 Oct
Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...Read more
Why-artificial-intelligence-is-not-fixing-the-problem-of-sepsis-in-the-hospital
2023 13 Oct
The use of Artificial Intelligence in detecting sepsis, AI prediction/detection models and how these healthcare tools need to complement clinical expertise. The potential of Artificial Intelligence (AI) in healthcare has generated significant excitement and discussion. However, it's important to distinguish between the theoretical...Read more
Genetically-predicted-insomnia-and-risk-of-sepsis
2023 11 Oct
Insomnia, a common sleep disorder, has been linked to various adverse health outcomes, including altered immune function and elevated systemic levels of inflammatory markers, which may affect women more than men. Dysregulated immune responses can lead to conditions like sepsis, which has high morbidity and mortality. A study was conducted to determine...Read more
Data-to-track-incidence-mortality-for-sars-cov-2-associated-sepsis
2023 03 Oct
Sepsis is a life-threatening condition resulting from a dysregulated response to infection, historically associated with bacterial infections. However, viral infections are increasingly recognised as significant contributors to sepsis, especially with events like the SARS-CoV-2 pandemic and surges of respiratory viruses like RSV and influenza. Despite...Read more
World-sepsis-day-lets-work-together-to-encourage-and-support-sepsis-research
2023 12 Sep
A woman came to see me a few days ago: her 44-year-old husband recently died from sepsis in another hospital, and she wanted to have a discussion about this tragic story. Her husband had had just some kind of blister on his foot. He didn’t seem very ill when he arrived at the hospital, but he quickly developed an extended area of fasciitis on his left...Read more
Corticosteroids-in-severe-cap
2023 12 Sep
Corticosteroid use in the care of critically ill patients has been the subject of ongoing research with conflicting findings. There is a growing interest in understanding their role in treating a common source of sepsis: community-acquired pneumonia (CAP). Some studies have focused on determining whether corticosteroids provide clinical benefits to...Read more
World-sepsis-day-understanding-symptoms-better
2023 08 Sep
World Sepsis Day falls on September 13. Sepsis, which kills more people in Austria each year than heart attacks, is caused by an infection which spreads through the body and damages our organs. A lot of people in the general public still do not know very much about this issue. Sepsis is one of the most common causes of death around the world....Read more
Angiotensin-ii-in-critically-ill-patients
2023 22 Aug
In December 2017, angiotensin II (ATII) intravenous infusion gained approval in the U.S. for treating septic or other distributive shock in adults. This approval was based on results from a phase II clinical trial which showed higher mean arterial pressure in septic shock patients on norepinephrine, who were randomly assigned to titrated ATII compared...Read more
The-promise-of-artificial-intelligence-in-critical-care
2023 01 Aug
Computer-based technologies, including artificial intelligence (AI) applications like ChatGPT and DALL-E, are being increasingly used and can mimic human capabilities, even passing medical board examinations. Retrospective studies have shown that machine learning (ML) applications are especially valuable in the ICU due to their diagnostic and prognostic...Read more