Search Tag: Sepsis
2020 14 Sep
Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research...Read more
2020 13 Jun
Sepsis biomarkers have an important role in the diagnosis, prognosis, and treatment of sepsis management. If timely and accurate information about biomarkers becomes available, the physician can not only make better therapeutic choices but also monitor the efficacy of the intervention in progress and adjust it accordingly. In a previous review...Read more
2020 03 Mar
Sepsis is a common condition encountered in hospitals and is associated with high morbidity and mortality. However, with advances in treatment, aggressive management and early institution of antibiotics, the number of sepsis survivors has increased. Each year in the US alone, over a million patients are discharged after being treated for sepsis....Read more
2020 18 Feb
Sepsis continues to be a leading cause of death in hospitalised patients. Approximately 1.7 million individuals develop sepsis each year in the US and of these, around 270,000 die from the infection. Sepsis affects nearly 30 million patients worldwide and nearly 6 million die from sepsis each year. Billions of dollars are required to manage sepsis,...Read more
2020 22 Jan
Sepsis is a life-threatening condition that causes nearly one-third to half of all hospital deaths. It is also responsible for more than 5 million deaths worldwide each year. Patients with septic shock are an important subgroup of sepsis. These patients have circulatory and metabolic abnormalities that further increase their mortality risk. New treatments...Read more
2020 15 Jan
Critical Care Medicine has existed for many years, but was only recognised as a specialty in the last 40 years or so. However, during this time, there has been a tremendous amount of change. Over the years, our understanding of different critical illnesses has improved, and our treatment strategies have become more effective. Technology has also played...Read more
2020 15 Jan
Improving early recognition of sepsis in the Neonatal Intensive Care Unit using machine learning models and electronic health record data. Neonatal Sepsis - Incidence and Outcomes Despite advances in knowledge and medical care, sepsis remains a major cause of morbidity and mortality in infants worldwide, claiming the lives of one...Read more
2020 15 Jan
Professor Rui P. Moreno works at the Intensive Care Unit of the Hospital de São José (Centro Hospitalar Universitário de Lisboa Central E.P.E) as the coordinator of the Neurocritical and Trauma ICU. Prof. Moreno has been a member of the European Society of Intensive Care Medicine (ESICM) since 1995 and became President of the Society in 2008. He...Read more
2020 15 Jan
Subject Index for Volume 19, issues 1-4, 2019. Issue Pages Link Issue 1 1-64 https://iii.hm/10cv Issue 2 65-128 https://iii.hm/10cw Issue 3 129-192 https://iii.hm/10cx Issue 4 193-256 https://iii.hm/10cy Acute Respiratory Distress Syndrome Use of sedation...Read more
2019 28 Dec
As we move into 2020, here's a quick recap of our most clicked stories in ICU in 2019: Using Biomarkers for Mortality Prediction in Patients With Sepsis A new study evaluated the prognostic value of six biomarkers at onset of sepsis in adult patients with sepsis or septic shock. Risk Factors for Frailty and Death in the ICU...Read more
2019 01 Dec
Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these...Read more
2019 23 Nov
Sepsis has always carried high mortality. Even today, with all the latest technology and newer antibiotics, sepsis continues to be a major risk factor for death. It is important to understand that the earlier sepsis is diagnosed and treated, the better the prognosis. Each year, nearly 6 million people die of sepsis in the US. Because of its aggressive...Read more
2019 14 Nov
Over the last few years, many advances have been made in the critical care of patients with septic shock. Both diagnosis and treatment strategies have improved. However, the mortality rates of patients with septic shock have a bimodal distribution; some patients die within a few days from it, while others die a few weeks later from other comorbidities. ...Read more
2019 21 Oct
Sepsis is a major cause of death among hospitalised patients. It affects nearly 6% of all admissions and results in in-hospital mortality of greater than 15%. Early detection could reduce mortality, as it would result in the timely implementation of evidence-based interventions. Clinical researchers have developed and implemented a machine-learning...Read more
2020 14 May
POSTPONED DUE TO COVID-19 HEALTH CONCERNS. DATES TO BE CONFIRMED Find ESICM on Social Media Read more
2019 04 Oct
Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just been published in JAMA. The CITRIS-ALI randomised trial addressed the use of high dose intravenous vitamin C to study...Read more
2019 26 Sep
The critically ill patient is often unable to feed by mouth. This condition, in some patients, can range from days to months. It is imperative that these patients receive macronutrients either through enteral or parenteral nutrition. If they don't, there is a risk of an energy deficit that could lead to loss of lean body mass and subsequently, other...Read more
2019 20 Sep
Severe bacterial infections pose a significant threat to public health, with 1.7 million people in the U.S. infected with sepsis every year. There has been a constant debate within medicine as to when treatment should be administered. Current guidelines state that blood cultures should be taken before antimicrobial treatment is initiated, as is...Read more
2019 13 Sep
In 2007, a study funded by the National Institutes of Health assessed the use of predictive models to calculate the risk of early-onset sepsis (EOS) in neonatal patients, accounting for multiple variables. The main objectives of the study were to assess the links between the risk factors and the infection outcomes; use patient data collected from...Read more
2019 25 Jul
Diagnosis of the Influenza virus remains a challenge in the ICU. It is vital that knowledge of its pathophysiology and epidemiology is known so clinicians can make informed decisions regarding their patients’ health. The Influenza virus is found most commonly to replicate in the respiratory tract in humans. This is mainly due to the haemagglutinin...Read more
2019 25 Jul
Existing biomarkers provide limited use for rapid detection of sepsis since they cannot accurately distinguish sepsis from other common conditions encountered in the emergency department (ED). Now a U.S. clinical trial suggests that the monocyte distribution width (MDW) can be a useful indicator of Sepsis-2 and Sepsis-3 in high-risk ED patients. "Changes...Read more
2019 09 Jul
The combination of intravenous vitamin C, corticosteroids and thiamine has been made famous by Dr. Paul Marik, M.D. for the treatment of sepsis in critically ill patients. The ‘Marik protocol’, also termed HAT (Hydrocortisone, Ascorbic acid, Thiamine), has however come under criticism regarding the lack of evidence. Dr. Marik of Sentara Norfolk...Read more
2019 26 Jun
The path to innovation is often based on intuition or insight. But the implementation of new ideas in healthcare requires rigorous testing and confirmation. However, one can argue that in the field of critical care, this cautious approach has let clinicians down. There is no doubt that clinical trials are important, but at the same time, they...Read more
2019 11 Jun
Sepsis is one of the most dangerous and life-threatening conditions encountered in the intensive care unit. Sepsis is considered to be an emergent disease similar to trauma, heart attack, and stroke. But sepsis is characterised by various aetiologies and pathophysiological conditions, and that is why it is very complicated to treat compared to...Read more
2019 30 May
Results of a study conducted by the University of Pittsburgh School of Medicine suggests that sepsis is not one condition, but many conditions that could benefit from different treatments. The findings are published in JAMA and were presented at the American Thoracic Society's Annual Meeting. Sepsis is the number one killer of hospitalised patients...Read more
2019 23 May
Sepsis affects millions of individuals every year. It carries a high risk of death, even if prompt care is provided. It has been decades, and no new therapies for sepsis have been discovered. A major barrier to progress in this area has been the overly broad definition for this syndrome. Sepsis has a vast array of clinical and biological features,...Read more
2019 01 May
A randomised controlled multicentre trial assessed for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 (anti–PD-L1) immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb, Princeton, NJ) and its effect on immune biomarkers in participants with sepsis-associated immunosuppression. Results show that...Read more
2019 23 Apr
Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure. This article, published in the journal Critical Care, proposes the concept of “broad spectrum vasopressors”...Read more