Search Tag: Sepsis

ICU Management

Isicem22-vasodilatory-choice-and-timing

2022 25 Mar

An article released in conjunction with the Intensive Care & Emergency Medicine (ISICEM) Congress helps clinicians understand the choice and timing of vasopressors in vasodilatory shock. It is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022.  Vasodilatory shock is one of the most common forms encountered...Read more

ICU Management

Sepsis-in-critical-care-3

2022 16 Mar

Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly  14 million adults and 2.5 million children  survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...Read more

ICU Management

One-sepsis-fits-all-are-there-different-phenotypes-of-sepsis-diagnostic-approaches-and-therapies

2022 16 Mar

This article presents current research results in relation to an advanced sepsis classification and their implications for new treatment options and research strategies. Introduction Through history, the definiti on and the term sepsis changed. Since Semmelweis and others formulated the thesis that sepsis was caused by a systemic reaction...Read more

ICU Management

Sepsis-in-critical-care-effective-antimicrobial-strategies-in-icu

2022 16 Mar

ICU sepsis is associated with a mortality rate >25%, with nosocomial infection most lethal, and community acquired infection more common. Optimal management requires identification of the site of infection (lung, abdomen and blood stream most commonly), a focus on the likely pathogens based on risk factors for resistance, and provision of timely and...Read more

ICU Management

The-alphabet-book-of-sepsis

2022 16 Mar

In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021)....Read more

ICU Management

Symmetrical-peripheral-gangrene

2022 16 Mar

In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in...Read more

ICU Management

Therapeutic-hyperthermia-and-survival-in-critically-ill-afebrile-sepsis-patients

2022 15 Feb

A major feature of infection is fever. However, less than half of critically ill patients with sepsis have a fever at the time of diagnosis. Afebrile patients with sepsis have nearly twice the mortality and are more likely to develop secondary infections than patients with fever. Fever is thus an adaptive response to the infection and is critical for...Read more

ICU Management

Ed-admission-and-adherence-to-surviving-sepsis-campaign-bundle

2022 15 Feb

Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid...Read more

ICU Management

Surviving-sepsis-campaign-guidelines-and-individualised-care

2021 29 Nov

Sepsis is a major cause of death in the ICU. It is a complex disease, and treatment is typically guided by evidence-based guidelines. However, it is important to remember that guidelines provide a systematic approach to patient evaluation and treatment decisions, but they are not a compilation of truth.   The Surviving Sepsis Campaign (SSC) Guidelines...Read more

ICU Management

Efficacy-appropriateness-of-antibiotic-use-in-the-icu

2021 09 Nov

The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients.   In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration...Read more

ICU Management

Microbiome-in-sepsis-and-covid-19

2021 30 Sep

Bacteria play a fundamental role in human life. Given the many roles of gut microbiota in critical illness and other pathological conditions, it is important to target therapeutical interventions to restore, preserve and enrich its composition. Introduction Bacteria play, for better or worse, a fundamental role in human life. As...Read more

ICU Management

Trends-in-sepsis-related-mortality-in-the-u-s

2021 27 Jul

Sepsis is a life-threatening organ dysfunction. It is the leading cause of death in the U.S. It is also one of the most expensive conditions to treat. However, the burden of sepsis-related mortality in the U.S. in recent years is not well-characterised. Previous studies utilise hospital databases and electronic health records to determine trends, but...Read more

ICU Management

Association-of-volume-of-sepsis-cases-and-mortality

2021 06 Jul

Sepsis is a leading cause of death worldwide and is also associated with a high burden of patient mortality.  This burden is expected to increase as populations age. Patients with sepsis typically require high-cost interventions in ICUs. Even with urgent treatment, the probability of death still remains high. However, ICUs that have more experience...Read more

ICU Management

Culture-negative-and-culture-positive-sepsis-or-septic-shock

2021 19 May

Incidence of sepsis and septic shock has been increasing consistently, and the morbidity and mortality associated with this is an area of concern. Mortality from sepsis and septic shock is quite high, ranging between 20 to 40%. Guidelines for sepsis and septic shock recommend the application of broad-spectrum antibiotics. There is clinical evidence...Read more

ICU Management

Antibiotic-delay-intervals-mortality-among-patients-with-suspected-sepsis

2021 27 Apr

Timely delivery of antibiotics is a major cornerstone of sepsis therapy. Clinical evidence suggests that every one-hour delay in antibiotics after emergency department (ED) triage or the onset of organ dysfunction or shock could result in a 3-7% increase in the odds of a poor outcome. The Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic...Read more

ICU Management

The-challenge-of-admitting-a-very-old-patient-with-sepsis-to-an-intensive-care-unit

2021 19 Apr

Sepsis incidence in very old patients is high and related mortality and morbidity are a major health concern. Frailty and severity of illness, not just age or sepsis diagnosis, are the determinant factors in outcome. Early identification and treatment are decisive in their survival. N owadays, we are facing some important facts: there has...Read more

ICU Management

Great-symposium-on-the-psp-sepsis-biomarker-hosted-by-abionic-and-palex-at-the-galisepsis-2021

2021 08 Apr

On April 6th, Abionic and Palex joined forces to participate in the first day of GaliSepsis, the National Sepsis Course hosted and organized virtually by the Ourense University Hospital Complex (CHUO) in Spain. With the aim of updating the most important concepts and reviewing the latest developments in the management of patients with sepsis, three...Read more

ICU Management

Biomarkers-to-identify-acute-kidney-injury-for-early-sepsis-detection

2021 23 Mar

Early recognition of sepsis is vital for improving patient outcomes. If detected on time, sepsis can be treated with antibiotics and source control, recognition and reversal of shock and organ support. The three most common organ dysfunctions in sepsis are cardiovascular, renal and respiratory. Cardiovascular and respiratory organ dysfunctions are...Read more

ICU Management

Resurgence-of-the-bun-creatinine-ratio-in-severe-illness-covid-19-sepsis-and-trauma-1

2021 31 Mar

Speakers John Toffaletti, Ph.D. Professor of Pathology, Director of ABG and CPED Labs Duke University Medical Center Dennis Begos, MD, FACS, FACRS Associate Medical Director, Medical and Scientific Affair Nova Biomedica l Find Nova Medical On Social Media Read more

ICU Management

Twenty-lessons-from-2020-with-a-focus-on-the-icu-perspective

2021 22 Feb

2020 has been an unusual year. As we begin 2021, it is important for intensivists to look back over what has happened and see whether lessons can be learned from our combined experiences . T he year 2020 has been unusual in so many ways and as we start a new year, it is interesting and important as intensivists to look back and reflect on what...Read more

ICU Management

44th-annual-conference-on-shock

2021 12 Oct

Find Shock Society On Social Media Read more

ICU Management

Orthos-vitros-r-b-r-a-h-m-s-pct-assay-for-sepsis-now-available

2020 06 Dec

Ortho Clinical Diagnostics , a global leader of in vitro diagnostics dedicated to improving and saving lives through innovative laboratory solutions, received CE Mark for its VITROS ®  B•R•A•H•M•S PCT (Procalcitonin) assay, now commercially available to help clinicians identify sepsis and other severe bacterial infections. Ortho’s newest assay is available...Read more

ICU Management

Atrial-fibrillation-and-sepsis-a-life-threatening-combination

2020 08 Oct

  Almost half of the patients with sepsis suffer from myocardial depression and a reduced ejection fraction. Sepsis can also cause changes in circulating volume, vascular tone, and coronary blood flow, all of which affect heart function and heart rate. Serum catecholamine levels and direct measurements of renal sympathetic nerve activity have shown...Read more

ICU Management

Early-identification-of-sepsis-web-symposium

2020 17 Nov

Speakers Prof. Dr Steven Opal Alpert Medical School of Brown University, USA Dr Bruno Francois Centre Hospitalier Universitaire de Limoges, France Dr Angelo Giacomucci Unita di Terapia Intensiva, Azienda Ospedaliera di Perugia, Italy Dr Phillipe Eggimann Centre Hopsitalier Universitaire Vaudois, Switzerland   Find Abionic on Social...Read more

ICU Management

Covid-19-still-poorly-understood

2020 02 Oct

During the first few months of the coronavirus disease, it was being suggested that severe COVID-19 may represent a hyperimmune disorder, similar to secondary haemophagocytic lymphohistiocytosis (sHLH) and macrophage activation syndrome (MAS). Cytokine storm, elevated plasma levels, ferritin and inflammatory biomarkers are all typical signs of sHLH/MAS....Read more

ICU Management

Promising-techniques-in-sepsis-after-cardiac-surgery

2020 14 Sep

The purpose of this article is to give an up-to-date, comprehensive review on the utilisation of extracorporeal blood purification techniques and immunostimulation in septic patients after cardiac surgery. Introduction Sepsis is a potentially life-threatening state caused by an infection and an inadequate, dysregulated host immune...Read more

ICU Management

Advances-in-sepsis-research-new-tools-against-one-of-the-oldest-diseases

2020 14 Sep

Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research...Read more