Search Tag: Sepsis
Isicem22-vasodilatory-choice-and-timing
2022 25 Mar
An article released in conjunction with the Intensive Care & Emergency Medicine (ISICEM) Congress helps clinicians understand the choice and timing of vasopressors in vasodilatory shock. It is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Vasodilatory shock is one of the most common forms encountered...Read more
Sepsis-in-critical-care-3
2022 16 Mar
Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly 14 million adults and 2.5 million children survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...Read more
One-sepsis-fits-all-are-there-different-phenotypes-of-sepsis-diagnostic-approaches-and-therapies
2022 16 Mar
This article presents current research results in relation to an advanced sepsis classification and their implications for new treatment options and research strategies. Introduction Through history, the definiti on and the term sepsis changed. Since Semmelweis and others formulated the thesis that sepsis was caused by a systemic reaction...Read more
Sepsis-in-critical-care-effective-antimicrobial-strategies-in-icu
2022 16 Mar
ICU sepsis is associated with a mortality rate >25%, with nosocomial infection most lethal, and community acquired infection more common. Optimal management requires identification of the site of infection (lung, abdomen and blood stream most commonly), a focus on the likely pathogens based on risk factors for resistance, and provision of timely and...Read more
The-alphabet-book-of-sepsis
2022 16 Mar
In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021)....Read more
Symmetrical-peripheral-gangrene
2022 16 Mar
In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in...Read more
Therapeutic-hyperthermia-and-survival-in-critically-ill-afebrile-sepsis-patients
2022 15 Feb
A major feature of infection is fever. However, less than half of critically ill patients with sepsis have a fever at the time of diagnosis. Afebrile patients with sepsis have nearly twice the mortality and are more likely to develop secondary infections than patients with fever. Fever is thus an adaptive response to the infection and is critical for...Read more
Ed-admission-and-adherence-to-surviving-sepsis-campaign-bundle
2022 15 Feb
Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid...Read more
Surviving-sepsis-campaign-guidelines-and-individualised-care
2021 29 Nov
Sepsis is a major cause of death in the ICU. It is a complex disease, and treatment is typically guided by evidence-based guidelines. However, it is important to remember that guidelines provide a systematic approach to patient evaluation and treatment decisions, but they are not a compilation of truth. The Surviving Sepsis Campaign (SSC) Guidelines...Read more
Efficacy-appropriateness-of-antibiotic-use-in-the-icu
2021 09 Nov
The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients. In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration...Read more
Microbiome-in-sepsis-and-covid-19
2021 30 Sep
Bacteria play a fundamental role in human life. Given the many roles of gut microbiota in critical illness and other pathological conditions, it is important to target therapeutical interventions to restore, preserve and enrich its composition. Introduction Bacteria play, for better or worse, a fundamental role in human life. As...Read more
Trends-in-sepsis-related-mortality-in-the-u-s
2021 27 Jul
Sepsis is a life-threatening organ dysfunction. It is the leading cause of death in the U.S. It is also one of the most expensive conditions to treat. However, the burden of sepsis-related mortality in the U.S. in recent years is not well-characterised. Previous studies utilise hospital databases and electronic health records to determine trends, but...Read more
Association-of-volume-of-sepsis-cases-and-mortality
2021 06 Jul
Sepsis is a leading cause of death worldwide and is also associated with a high burden of patient mortality. This burden is expected to increase as populations age. Patients with sepsis typically require high-cost interventions in ICUs. Even with urgent treatment, the probability of death still remains high. However, ICUs that have more experience...Read more
Culture-negative-and-culture-positive-sepsis-or-septic-shock
2021 19 May
Incidence of sepsis and septic shock has been increasing consistently, and the morbidity and mortality associated with this is an area of concern. Mortality from sepsis and septic shock is quite high, ranging between 20 to 40%. Guidelines for sepsis and septic shock recommend the application of broad-spectrum antibiotics. There is clinical evidence...Read more
Antibiotic-delay-intervals-mortality-among-patients-with-suspected-sepsis
2021 27 Apr
Timely delivery of antibiotics is a major cornerstone of sepsis therapy. Clinical evidence suggests that every one-hour delay in antibiotics after emergency department (ED) triage or the onset of organ dysfunction or shock could result in a 3-7% increase in the odds of a poor outcome. The Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic...Read more
The-challenge-of-admitting-a-very-old-patient-with-sepsis-to-an-intensive-care-unit
2021 19 Apr
Sepsis incidence in very old patients is high and related mortality and morbidity are a major health concern. Frailty and severity of illness, not just age or sepsis diagnosis, are the determinant factors in outcome. Early identification and treatment are decisive in their survival. N owadays, we are facing some important facts: there has...Read more
Great-symposium-on-the-psp-sepsis-biomarker-hosted-by-abionic-and-palex-at-the-galisepsis-2021
2021 08 Apr
On April 6th, Abionic and Palex joined forces to participate in the first day of GaliSepsis, the National Sepsis Course hosted and organized virtually by the Ourense University Hospital Complex (CHUO) in Spain. With the aim of updating the most important concepts and reviewing the latest developments in the management of patients with sepsis, three...Read more
Biomarkers-to-identify-acute-kidney-injury-for-early-sepsis-detection
2021 23 Mar
Early recognition of sepsis is vital for improving patient outcomes. If detected on time, sepsis can be treated with antibiotics and source control, recognition and reversal of shock and organ support. The three most common organ dysfunctions in sepsis are cardiovascular, renal and respiratory. Cardiovascular and respiratory organ dysfunctions are...Read more
Resurgence-of-the-bun-creatinine-ratio-in-severe-illness-covid-19-sepsis-and-trauma-1
2021 31 Mar
Speakers John Toffaletti, Ph.D. Professor of Pathology, Director of ABG and CPED Labs Duke University Medical Center Dennis Begos, MD, FACS, FACRS Associate Medical Director, Medical and Scientific Affair Nova Biomedica l Find Nova Medical On Social Media Read more
Twenty-lessons-from-2020-with-a-focus-on-the-icu-perspective
2021 22 Feb
2020 has been an unusual year. As we begin 2021, it is important for intensivists to look back over what has happened and see whether lessons can be learned from our combined experiences . T he year 2020 has been unusual in so many ways and as we start a new year, it is interesting and important as intensivists to look back and reflect on what...Read more
Orthos-vitros-r-b-r-a-h-m-s-pct-assay-for-sepsis-now-available
2020 06 Dec
Ortho Clinical Diagnostics , a global leader of in vitro diagnostics dedicated to improving and saving lives through innovative laboratory solutions, received CE Mark for its VITROS ® B•R•A•H•M•S PCT (Procalcitonin) assay, now commercially available to help clinicians identify sepsis and other severe bacterial infections. Ortho’s newest assay is available...Read more
Atrial-fibrillation-and-sepsis-a-life-threatening-combination
2020 08 Oct
Almost half of the patients with sepsis suffer from myocardial depression and a reduced ejection fraction. Sepsis can also cause changes in circulating volume, vascular tone, and coronary blood flow, all of which affect heart function and heart rate. Serum catecholamine levels and direct measurements of renal sympathetic nerve activity have shown...Read more
Esem-2020-emirates-society-of-emergency-medicine-conference
2020 10 Dec
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Early-identification-of-sepsis-web-symposium
2020 17 Nov
Speakers Prof. Dr Steven Opal Alpert Medical School of Brown University, USA Dr Bruno Francois Centre Hospitalier Universitaire de Limoges, France Dr Angelo Giacomucci Unita di Terapia Intensiva, Azienda Ospedaliera di Perugia, Italy Dr Phillipe Eggimann Centre Hopsitalier Universitaire Vaudois, Switzerland Find Abionic on Social...Read more
Covid-19-still-poorly-understood
2020 02 Oct
During the first few months of the coronavirus disease, it was being suggested that severe COVID-19 may represent a hyperimmune disorder, similar to secondary haemophagocytic lymphohistiocytosis (sHLH) and macrophage activation syndrome (MAS). Cytokine storm, elevated plasma levels, ferritin and inflammatory biomarkers are all typical signs of sHLH/MAS....Read more
Promising-techniques-in-sepsis-after-cardiac-surgery
2020 14 Sep
The purpose of this article is to give an up-to-date, comprehensive review on the utilisation of extracorporeal blood purification techniques and immunostimulation in septic patients after cardiac surgery. Introduction Sepsis is a potentially life-threatening state caused by an infection and an inadequate, dysregulated host immune...Read more
Advances-in-sepsis-research-new-tools-against-one-of-the-oldest-diseases
2020 14 Sep
Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research...Read more