Search Tag: Sepsis
2022 14 Jun
Fever is an important feature of infection. However, fewer than half of patients with sepsis present with fever at the time of diagnosis. Afebrile sepsis patients have nearly twice the mortality and are at a higher risk of developing secondary infections than patients with fever. Fever is an adaptive response to infection that may be critical...Read more
2022 10 Jun
Sepsis is a condition commonly encountered in critically ill patients. However, the management of sepsis varies globally and mainly depends on the availability of resources. Sepsis-related mortality tends to be higher in countries with limited resources. In this study, the researchers summarise evidence regarding sepsis protocols and their compliances...Read more
2022 06 Jun
1. Sepsis: the Need for Speed Sepsis is a life-threatening form of organ dysfunction caused by a dysregulated host response to infection 1 . This extremely heterogeneous and dynamic syndrome is the result of complex interactions between invading microorganisms and the host’s immune system. Disruption of the host’s ability to maintain immune homeostasis...Read more
2022 31 May
Sepsis is one of the most challenging complications in the ICU. It is a physiologic response to infection that could lead to multiorgan failure and death if not managed and treated properly. Sepsis is a major health issue in the U.S., with more than 1.7 million cases diagnosed annually. Sepsis is also a leading cause of death and one of the most expensive...Read more
2022 25 May
An overview of a discussion on sepsis and the Pancreatic Stone Protein (PSP) biomarker by Dr João Pereira, Hospital De Vila Franca De Xira, Portugal and how it can be used for early diagnosis of sepsis and facilitate decision-making regarding the administration of antibiotics. The discussion was chaired by Prof Pedro Póvoa, coordinator of...Read more
2022 17 May
Sepsis is a heterogeneous syndrome. It has varying characteristics and therapeutic items depending on the patient’s background, socio-economic status, geographic reason, causative pathogens, site of infection, host responses and quality of care. This heterogeneity makes the management of sepsis even more challenging and hinders clinical research planning....Read more
2022 27 Apr
The risk of late mortality in sepsis survivors can persist for years with high readmission rates and poor quality of life. However, due to an incomplete understanding of the relevant causal mechanisms of post-sepsis syndrome, there has been limited success in implementing preventive interventions. The French and European Outcome Registry in Intensive...Read more
2022 21 Apr
Based in Switzerland, Abionic is an in vitro diagnostic company, uniquely positioned at the intersection of medical technology, biotechnology and nanotechnology. The company has developed an unparalleled nanofluidic technology-based platform, the abioSCOPE® to offer patients fast blood test results right at the Point-of-Care (PoC). The abioSCOPE® is...Read more
2022 25 Mar
An article released in conjunction with the Intensive Care & Emergency Medicine (ISICEM) Congress helps clinicians understand the choice and timing of vasopressors in vasodilatory shock. It is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Vasodilatory shock is one of the most common forms encountered...Read more
2022 16 Mar
Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly 14 million adults and 2.5 million children survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...Read more
2022 16 Mar
This article presents current research results in relation to an advanced sepsis classification and their implications for new treatment options and research strategies. Introduction Through history, the definiti on and the term sepsis changed. Since Semmelweis and others formulated the thesis that sepsis was caused by a systemic reaction...Read more
2022 16 Mar
ICU sepsis is associated with a mortality rate >25%, with nosocomial infection most lethal, and community acquired infection more common. Optimal management requires identification of the site of infection (lung, abdomen and blood stream most commonly), a focus on the likely pathogens based on risk factors for resistance, and provision of timely and...Read more
2022 16 Mar
In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021)....Read more
2022 16 Mar
In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in...Read more
2022 15 Feb
A major feature of infection is fever. However, less than half of critically ill patients with sepsis have a fever at the time of diagnosis. Afebrile patients with sepsis have nearly twice the mortality and are more likely to develop secondary infections than patients with fever. Fever is thus an adaptive response to the infection and is critical for...Read more
2022 15 Feb
Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid...Read more
2021 29 Nov
Sepsis is a major cause of death in the ICU. It is a complex disease, and treatment is typically guided by evidence-based guidelines. However, it is important to remember that guidelines provide a systematic approach to patient evaluation and treatment decisions, but they are not a compilation of truth. The Surviving Sepsis Campaign (SSC) Guidelines...Read more
2021 09 Nov
The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients. In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration...Read more
2021 04 Oct
Real world evidence on the practical implementation of the Pancreatic Stone Protein (PSP) Sepsis Test On the 22nd of September, attendees tuned in to a lively discussion on sepsis chaired by Professor Pedro Póvoa, who is currently coordinator of the Intensive Care Unit (ICU) in one of the largest hospitals in Lisbon and who is no stranger to the...Read more
2021 30 Sep
Bacteria play a fundamental role in human life. Given the many roles of gut microbiota in critical illness and other pathological conditions, it is important to target therapeutical interventions to restore, preserve and enrich its composition. Introduction Bacteria play, for better or worse, a fundamental role in human life. As...Read more