A pioneering clinical trial is testing whether ultrasound therapy can relieve pain in patients whose cancers have spread to the bone. The first five patients have already been treated in the trial, with encouraging reductions in the pain they were experiencing from bone tumours, according to researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust.
The technique called high-intensity focused ultrasound (HIFU) concentrates ultrasound energy precisely on a target in the body to thermally destroy tissue. The technology is coupled with magnetic resonance imaging (MRI) guidance to identify, target and track treatment in real time. The treatment produces heat to destroy the nerve tissue in the bone around the tumour causing the pain, while leaving adjacent areas unharmed.
“Focused ultrasound is an exciting potential cancer treatment because of its ability to target tumours very precisely," study co-leader Gail ter Haar, Professor of Therapeutic Ultrasound at the ICR. "The point onto which the ultrasound beam is focused gets very hot, but the surrounding tissue is left unharmed. It’s like using a magnifying glass in the sun to start a fire, where you need to form a sharp focal spot on the dry tinder.”
Patients whose cancers have metastasised to the bone can experience intense bone pain, which can severely reduce their quality of life. HIFU could provide a non-invasive way of controlling pain for these patients where radiotherapy is no longer an option, or where other treatments have been unable to control the disease.
Royal Marsden patient Moira Rogers was the first patient to go on the clinical trial. She said: “Being on this trial has meant a great deal to me. It has helped get the pain I was in under control and given me my quality of life back. Trials like these are extremely important and I am so glad I have been given the opportunity by my doctors at The Royal Marsden to be part of this ground breaking study.”
Ultrasound has traditionally been used as a way of imaging the body but, used at higher power, researchers believe it offers promise as an exciting new way of treating cancer. If this HIFU study proves successful for pain control, it could lead to further studies at ICR and the Royal Marsden to thermally destroy local tumours at an earlier stage of the disease, possibly helping to extend life.
“We’re still learning how best to use focused ultrasound, but we believe it has real potential for improving the quality of life of patients with advanced cancer," study co-leader Nandita deSouza, Professor of Translational Imaging at the ICR and Honorary Consultant at the Royal Marsden. "It is early days in our trial, but we hope ultrasound therapy will prove effective at reducing the pain caused by bone metastases, and offer the chance for patients to live the final stages of their lives much more comfortably.”
The trial is part of a wider initiative between the ICR, The Royal Marsden, the Focused Ultrasound Foundation and Philips, the developer of the HIFU system. This collaboration is creating a state-of-the-art resource for clinicians and scientists to establish global standards for focused ultrasound and accelerate development of the technology to treat cancers.
“MR imaging is emerging in oncology applications, because of its excellent real-time 3D visualisation of both soft tissue anatomy and physiological processes”, said Christopher Busch, General Manager MR Therapy at Philips. “Combining focused ultrasound thermal therapies with real-time MR imaging and monitoring is a powerful concept that has the potential to become a new precision treatment tool in oncology.”
Source: Philips N.V.
Image Credit: Philips N.V.
The technique called high-intensity focused ultrasound (HIFU) concentrates ultrasound energy precisely on a target in the body to thermally destroy tissue. The technology is coupled with magnetic resonance imaging (MRI) guidance to identify, target and track treatment in real time. The treatment produces heat to destroy the nerve tissue in the bone around the tumour causing the pain, while leaving adjacent areas unharmed.
“Focused ultrasound is an exciting potential cancer treatment because of its ability to target tumours very precisely," study co-leader Gail ter Haar, Professor of Therapeutic Ultrasound at the ICR. "The point onto which the ultrasound beam is focused gets very hot, but the surrounding tissue is left unharmed. It’s like using a magnifying glass in the sun to start a fire, where you need to form a sharp focal spot on the dry tinder.”
Patients whose cancers have metastasised to the bone can experience intense bone pain, which can severely reduce their quality of life. HIFU could provide a non-invasive way of controlling pain for these patients where radiotherapy is no longer an option, or where other treatments have been unable to control the disease.
Royal Marsden patient Moira Rogers was the first patient to go on the clinical trial. She said: “Being on this trial has meant a great deal to me. It has helped get the pain I was in under control and given me my quality of life back. Trials like these are extremely important and I am so glad I have been given the opportunity by my doctors at The Royal Marsden to be part of this ground breaking study.”
Ultrasound has traditionally been used as a way of imaging the body but, used at higher power, researchers believe it offers promise as an exciting new way of treating cancer. If this HIFU study proves successful for pain control, it could lead to further studies at ICR and the Royal Marsden to thermally destroy local tumours at an earlier stage of the disease, possibly helping to extend life.
“We’re still learning how best to use focused ultrasound, but we believe it has real potential for improving the quality of life of patients with advanced cancer," study co-leader Nandita deSouza, Professor of Translational Imaging at the ICR and Honorary Consultant at the Royal Marsden. "It is early days in our trial, but we hope ultrasound therapy will prove effective at reducing the pain caused by bone metastases, and offer the chance for patients to live the final stages of their lives much more comfortably.”
The trial is part of a wider initiative between the ICR, The Royal Marsden, the Focused Ultrasound Foundation and Philips, the developer of the HIFU system. This collaboration is creating a state-of-the-art resource for clinicians and scientists to establish global standards for focused ultrasound and accelerate development of the technology to treat cancers.
“MR imaging is emerging in oncology applications, because of its excellent real-time 3D visualisation of both soft tissue anatomy and physiological processes”, said Christopher Busch, General Manager MR Therapy at Philips. “Combining focused ultrasound thermal therapies with real-time MR imaging and monitoring is a powerful concept that has the potential to become a new precision treatment tool in oncology.”
Source: Philips N.V.
Image Credit: Philips N.V.
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Ultrasound, Philips, Oncology, Tumours, metastases, bone
A pioneering clinical trial is testing whether ultrasound therapy can relieve pain in patients whose cancers have spread to the bone. The first five patien...
