HighFlow double lumen catheters with Dolphin coating have been created using a reactive copolymer coating with a mircrodomain surface structure that mimics the natural surface of cells or proteins. Uncoated catheter surfaces are exposed to surface degradation due to the wash out of Barium sulfate particles when coming into contact with blood components. This causes clotting responses and accumulating occlusive HighFlow double lumen catheters with Dolphin coating have been created using a reactive copolymer coating with a mircrodomain surface structure that mimics the natural surface of cells or proteins. Hydrophyllic and hydrophobic domains in nanometer range fail to interact with microdomains of cell membranes or proteins. This non-eluting coating creates a smooth surface on the catheter shaft and lumen, preventing surface degradation.