The CRYO FORMER is based on the principle of cryo-iontophoresis which is an improved classic iontophoresis method. The medication solution is applied to the treatment site in the form of a rolling ice cup representing an active electrode. This approach ensures that the concentration of active substance penetrating the skin do not change during therapy. It also ensures larger drug amount reaches the target tissue beneath the skin surface since this approach also decreases skin resistance using the current frequency of 4000Hz. The ice prevents common side effects of iontophoresis such as skin reddening, blistering, petechiae and burns as well.