CytoStar-T scintillating microplates are designed for non-invasive quantitation in real-time analysis of a wide spectrum of biological reactions in cells under normal physiological conditions. Analyses include cell adhesion, cell signaling (e.g., receptor-ligand binding), cell motility, cell proliferation, normal cellular metabolism, metabolite transport, as well as drug processing (intake and efflux). The technology, which was first developed in 96-well plate format, but is now available in 384-well plate format in response to the increased demand for a higher throughput solution. CytoStar-T scintillating microplates conform to SBS-standards in both the 96-well and 384-well formats. They are sterile, tissue culture treated microplates designed not only for the growth of adherent but also suspension cell cultures (after plate centrifugation or cells settle). The integral, planar, transparent base of each well is composed of a proprietary homogeneous mixture of scintillants and polystyrene. The transparent nature of the base permits the observation of growth of cells plated in the well. Furthermore, radioisotopes having suitable decay characteristics (3H, 14C, 35S, 33P, 45Ca, 125I), brought into proximity with the scintillant contained within the base by virtue of the biological processes within the cells, will have that radioactive decay converted to a light signal. This blue light signal can then be detected and quantified using a PMT-based radiometric detection instrument, like PerkinElmer's MicroBeta2. The amount of light generated is proportional to the amount of radioisotope within, or associated with, the cells.