Volume 25 - Issue 2, 2025

Sepsis remains one of the most daunting challenges in critical care. An estimated 49 million cases of sepsis occur globally every year, and it affects 1 in 5 people worldwide. Sepsis is responsible for 11 million deaths each year — this accounts for 20% of all global deaths. Sepsis and Acute Respiratory Distress Syndrome (ARDS) are closely linked in critically ill patients. In fact, sepsis is the m...

Sepsis and Acute Respiratory Distress Syndrome (ARDS) are heterogeneous critical illness syndromes. Molecular subphenotyping shows promise in furthering our understanding of these syndromes and may offer a more precise method for identifying appropriate therapies. Sepsis and the acute respiratory distress syndrome (ARDS) are heterogeneous clinical entities that afflict critically ill patients. Bas...

Artificial intelligence (AI) plays an evolving role in optimising sepsis management and SEP-1 compliance. Despite these advances, barriers persist, including alert fatigue, disparities in model performance across diverse settings, and regulatory hurdles in AI deployment. By integrating predictive models with structured team-based interventions, healthcare institutions can improve early recognition, enhance...

Pancreatic Stone Protein (PSP) is a valuable early biomarker for sepsis. Given its kinetics and accessibility, PSP may aid in identifying patients at risk of progressing to ARDS, particularly within the hyperinflammatory phenotype. Acute respiratory distress syndrome (ARDS) is defined by hypoxaemic respiratory failure, bilateral pulmonary infiltrates, and non-cardiogenic pulmonary oedema. It affect...

Elevated lactate levels indicate higher morbidity and mortality but require careful interpretation. In the presence of tissue hypoperfusion, they should prompt urgent haemodynamic optimisation. Without such signs, they warrant reassessing diagnosis and treatment. Serial lactate levels guide overall management but have limitations, and clinicians must understand the complexities of lactate metabolism in pat...

Both sepsis and Acute Respiratory Distress Syndrome (ARDS) are major determinants of morbidity and mortality in the ICU, and sepsis is often complicated by ARDS. We discuss the role of corticosteroids in these patients. Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that can be the result of several underlying conditions such as pneumonia, aspiration, trauma, pancreatitis an...

Clinical insights on the use of beta-blockers and vasopressors in the ICU, focusing on landiolol and vasopressin. When managing cardiovascular instability in critically ill patients, intensivists often face a delicate balancing act: controlling heart rate without compromising haemodynamics and maintaining perfusion without excessive vasopressor burden. In a recent AOP Health-sponsored symposium...

This article highlights sepsis early recognition and prevention to reduce the risk of developing sepsis-induced ARDS while emphasising pathophysiology, early recognition, and early intervention for both conditions. Sepsis, a life-threatening condition caused by a dysregulated immune response to infection, is a preventable global health crisis (Singer et al. 2016). A report in 2020 indicated that ar...

Sepsis-induced ARDS is a critical condition that may require anti-inflammatory strategies. There are some promising treatments that may alter the evolution, including corticosteroids, vitamin C, NET inhibitors, and statins, which help mitigate excessive immune response and improve clinical outcomes. Sepsis represents a heterogeneous life-threatening condition triggered by acute infection and charac...

The management of acute respiratory distress syndrome (ARDS) in traumatic brain injury (TBI) patients presents unique challenges due to the need for lung-protective ventilation while maintaining cerebral perfusion. This article examines optimal ventilation strategies, oxygenation targets, fluid management, and adjunctive therapies to balance pulmonary and neurological outcomes in critically ill patients....

Phosphate-based solutions used during continuous renal replacement therapy (CRRT) significantly reduce the incidence of hypophosphataemia in critically ill patients. These solutions are safe, improve phosphate balance, and may shorten ICU stay and ventilation duration, though further multicentre trials are needed to confirm these benefits. Phosphate plays a vital role in energy metabolism, cellular...

High levels of mechanical power are associated with a higher incidence of lung damage and worse outcomes in patients with Acute Respiratory Distress Syndrome. This article explores the fundamentals of mechanical power, proper regulation of ventilatory support and the prevention of lung damage associated with mechanical ventilation. Acute respiratory distress syndrome (ARDS) is a condition character...

Sepsis and ARDS are complex syndromes where point-of-care testing and biomarker-guided, personalised treatments offer growing promise. With high mortality, prolonged recovery, and emerging therapies like anti-fibrotics, even small gains may be cost-effective. Sepsis and Acute Respiratory Distress Syndrome (ARDS) are both clinical syndromes with a high mortality and morbidity burden on the intensive...

For a full listing of events visit https://iii.hm/icuevents2025 International Conference on Emergency Medicine 23-28 Montreal, Canada https://iii.hm/1uxi Euro-China Forum 2025 23-25 Changsha City, China https://iii.hm/1uxj 25-27 Euroanaesthesia 2025 Lisbon, Portugal https://iii.hm/1uxk 2025 Canadian Critical Care Review 1-3 Toronto, Canada https://iii.hm...